Morpholine, 4-(3-azetidinyl)-, dihydrochloride

Base Information

• Chemical Name: Morpholine, 4-(3-azetidinyl)-, dihydrochloride
• CAS No.: 178312-50-0
• Molecular Formula: C7H14N2O.2ClH
• Molecular Weight: 215.12100
• Hs Code.: 2934999090
• Mol file: 178312-50-0.mol

Synonyms:4-(azetidin-3-yl)morpholine,dihydrochloride;

Chemical Property of Morpholine, 4-(3-azetidinyl)-, dihydrochloride

Chemical Property:

• PSA: 24.50000
• LogP: 1.16110
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(Azetidin-3-yl)morpholineDihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Morpholine, 4-(3-azetidinyl)-, dihydrochloride

There total 4 articles about Morpholine, 4-(3-azetidinyl)-, dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tert-butyl 3-morpholinoazetidine-1-carboxylate (1290136-89-8) → 4-(3-azetidinyl)morpholine dihydrochloride (178312-50-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 16h;

Reference yield: 50.5%

morpholine (110-91-8,99108-56-2) + 3-methanesulfonyloxy-azetidine-1-carboxylic acid tert-butyl ester (141699-58-3) → 4-(3-azetidinyl)morpholine dihydrochloride (178312-50-0)

Guidance literature:

morpholine; 3-methanesulfonyloxy-azetidine-1-carboxylic acid tert-butyl ester; With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 103 ℃; for 12h;

With hydrogenchloride; In methanol; for 3h; Heating / reflux;

Reference yield:

→ 4-(3-azetidinyl)morpholine dihydrochloride (178312-50-0)

Guidance literature:

upstream raw materials:

morpholine

3-methanesulfonyloxy-azetidine-1-carboxylic acid tert-butyl ester

tert-butyl 3-morpholinoazetidine-1-carboxylate

Refernces

• 1、 -. "PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH". Page/Page column 86-87. . Retrieved 2010/11/27.
• 2、 -. "(Azetidin-1-ylalkyl) lactams as tachykinin antagonists". . . Retrieved 2008/06/13.