Cyclooctanone, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-7-(4-hydroxy-1-methylenebutyl)-5 -[(4-methoxyphenyl)methoxy]-4,4-dimethyl-2,6-bis(phenylmethoxy)-, (2R,3R,5R,6S,7S)-

Base Information

Chemical Name:Cyclooctanone, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-7-(4-hydroxy-1-methylenebutyl)-5 -[(4-methoxyphenyl)methoxy]-4,4-dimethyl-2,6-bis(phenylmethoxy)-, (2R,3R,5R,6S,7S)-
CAS No.:178626-14-7
Molecular Formula:C43H60O7Si
Molecular Weight:717.031
Hs Code.:

Cyclooctanone,
3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-7-(4-hydroxy-1-methylenebutyl)-5
-[(4-methoxyphenyl)methoxy]-4,4-dimethyl-2,6-bis(phenylmethoxy)-,
(2R,3R,5R,6S,7S)-

Synonyms:

Suppliers and Price of Cyclooctanone, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-7-(4-hydroxy-1-methylenebutyl)-5 -[(4-methoxyphenyl)methoxy]-4,4-dimethyl-2,6-bis(phenylmethoxy)-, (2R,3R,5R,6S,7S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of Cyclooctanone, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-7-(4-hydroxy-1-methylenebutyl)-5 -[(4-methoxyphenyl)methoxy]-4,4-dimethyl-2,6-bis(phenylmethoxy)-, (2R,3R,5R,6S,7S)-

Chemical Property:

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Cyclooctanone, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-7-(4-hydroxy-1-methylenebutyl)-5 -[(4-methoxyphenyl)methoxy]-4,4-dimethyl-2,6-bis(phenylmethoxy)-, (2R,3R,5R,6S,7S)-

There total 2 articles about Cyclooctanone, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-7-(4-hydroxy-1-methylenebutyl)-5 -[(4-methoxyphenyl)methoxy]-4,4-dimethyl-2,6-bis(phenylmethoxy)-, (2R,3R,5R,6S,7S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 64180-78-5
4-bromopent-4-en-1-ol

: (4S,5R,7R,8R)-4,8-Dibenzyloxy-7-(tert-butyldimethylsiloxy)-5-(p-methoxybenzyloxy)-6,6-dimethyl-2-cycloocten-1-one

: 178626-14-7
(2R,3R,5R,6S,7R)-2,6-Dibenzyloxy-3-(tert-butyldimethylsiloxy)-7-[1-(3-hydroxypropyl)vinyl]-5-(p-methoxybenzyloxy)-4,4-dimethylcyclooctanone

Guidance literature:: 4-bromopent-4-en-1-ol; With tert.-butyl lithium; In diethyl ether; pentane; at -78 ℃; for 0.5h;

With thien-2-yl(cyano)copper lithium; In tetrahydrofuran; diethyl ether; pentane; at -78 ℃; for 0.583333h;

(4S,5R,7R,8R)-4,8-Dibenzyloxy-7-(tert-butyldimethylsiloxy)-5-(p-methoxybenzyloxy)-6,6-dimethyl-2-cycloocten-1-one; In tetrahydrofuran; diethyl ether; pentane; at -45 - 0 ℃; for 0.833333h;
DOI:10.1002/(sici)1521-3765(19990104)5:1<121::aid-chem121>3.3.co;2-f

Reference yield:

: 35804-44-5
ethyl 4-bromo-4-pentenoate

: 178626-14-7
(2R,3R,5R,6S,7R)-2,6-Dibenzyloxy-3-(tert-butyldimethylsiloxy)-7-[1-(3-hydroxypropyl)vinyl]-5-(p-methoxybenzyloxy)-4,4-dimethylcyclooctanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: LiAlH₄ / tetrahydrofuran / 0.67 h / 0 °C

2.1: t-BuLi / diethyl ether; pentane / 0.5 h / -78 °C

2.2: lithium 2-thienylcyanocuprate / tetrahydrofuran; diethyl ether; pentane / 0.58 h / -78 °C

2.3: 91 percent / tetrahydrofuran; diethyl ether; pentane / 0.83 h / -45 - 0 °C

With lithium aluminium tetrahydride; tert.-butyl lithium; In tetrahydrofuran; diethyl ether; pentane; 1.1: Reduction / 2.1: Metallation / 2.2: Substitution / 2.3: Addition;
DOI:10.1002/(sici)1521-3765(19990104)5:1<121::aid-chem121>3.3.co;2-f