2-HYDROXYCARBAZOLE

Base Information

• Chemical Name: 2-HYDROXYCARBAZOLE
• CAS No.: 86-79-3
• Molecular Formula: C12H9NO
• Molecular Weight: 183.21
• Hs Code.: 2933990090
• European Community (EC) Number: 201-699-7
• UNII: SH4E4EQ2YZ
• DSSTox Substance ID: DTXSID50235340
• Nikkaji Number: J192.640C
• Wikidata: Q72483468
• ChEMBL ID: CHEMBL1170901
• Mol file: 86-79-3.mol

Synonyms:Carbazol-2-ol(6CI,7CI,8CI);2-Hydroxy-9H-carbazole;2-Hydroxycarbazole;

Chemical Property of 2-HYDROXYCARBAZOLE

Chemical Property:

• Appearance/Colour: beige to light brown crystalline powder
• Vapor Pressure: 4.78E-08mmHg at 25°C
• Melting Point: 270-273 °C (lit. )
• Refractive Index: 1.815
• Boiling Point: 431.4 °C at 760 mmHg
• PKA: 10.05±0.30(Predicted)
• Flash Point: 214.7 °C
• PSA: 36.02000
• Density: 1.362 g/cm³
• LogP: 3.02670
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 183.068413911
• Heavy Atom Count: 14
• Complexity: 218

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Hydroxycarbazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi, C, F, T
• Hazard Codes: Xi,C,T,F
• Statements: 36/37/38-34
• Safety Statements: 26-36-37/39-45-36/37/39-27

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C3=C(N2)C=C(C=C3)O
• Uses: Carbazol has been found possible to distinguish between heparin, heparin derivatives, and other polyuronides of connective tissue. A new modification of the carbazole analysis is useful for determination of d-mannuronic acid in heteropolysaccharides. 2-Hydroxycarbazole was used in the synthesis of isochromene fused carbazol, (4aS,13bR)-2,5,5-trimethyl-3,4,4a,5,8,13b-hexahydroisochromeno[3,4-b]carbazole.

Technology Process of 2-HYDROXYCARBAZOLE

There total 17 articles about 2-HYDROXYCARBAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

9-ethoxycarbonyl-2-hydroxycarbazole → 2-hydroxycarbazole (86-79-3)

Guidance literature:

With potassium hydroxide; In methanol; Heating;

DOI:10.1016/S0040-4039(01)00854-1

Reference yield: 40.0%

2,2-dimethyl-5-(2-methylindol-3-ylmethylene)-1,3-dioxane-4,6-dione (76834-74-7) → 2-hydroxycarbazole (86-79-3)

Guidance literature:

at 600 ℃; under 0.001 - 0.01 Torr;

Reference yield: 37.0%

2'-iodo-[1,1'-biphenyl]-4-ol (1429337-46-1) → 2-hydroxycarbazole (86-79-3)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 150 ℃; for 48h; Inert atmosphere; Schlenk technique; Molecular sieve;

DOI:10.1039/c3cc41443d

upstream raw materials:

2-chloro-9H-carbazole

5,6,7,8-tetrahydro-carbazol-2-ol

2-ethoxycarbazole

2'-Azido-biphenyl-4-ol

Downstream raw materials:

2-methoxy-9H-carbazole

2-Hydroxycarbazole-3-carboxylic acid

2-hydroxy-9H-carbazole-1-carboxylic acid

C₂₂H₁₇NO₂

Refernces

• 1、 Sanz, Roberto,Escribano, Jaime,Pedrosa, Maria R.,Aguado, Rafael,Arnaiz, Francisco J.. "Dioxomolybdenum(VI)-catalyzed reductive cyclization of nitroaromatics. Synthesis of carbazoles and indoles". . p. 713 - 718. Retrieved 2008/02/09.
• 2、 -. "Use of ion channel modulating agents". . . Retrieved 2008/06/13.