4-Amino-5-chloro-3-iodo-2-methoxybenzoic acid

Base Information

Chemical Name:4-Amino-5-chloro-3-iodo-2-methoxybenzoic acid
CAS No.:179872-39-0
Molecular Formula:C8H7ClINO3
Molecular Weight:327.506
Hs Code.:
DSSTox Substance ID:DTXSID10706844
Wikidata:Q82640393
Mol file:179872-39-0.mol

Synonyms:4-Amino-5-chloro-3-iodo-2-methoxybenzoic acid;179872-39-0;SCHEMBL7357713;DTXSID10706844

Suppliers and Price of 4-Amino-5-chloro-3-iodo-2-methoxybenzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 4-Amino-5-chloro-3-iodo-2-methoxybenzoic acid

Chemical Property:

XLogP3:2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:326.91592
Heavy Atom Count:14
Complexity:229

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C(=C(C=C1C(=O)O)Cl)N)I

Technology Process of 4-Amino-5-chloro-3-iodo-2-methoxybenzoic acid

There total 10 articles about 4-Amino-5-chloro-3-iodo-2-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: methyl 4-amino-5-chloro-3-iodo-2-methoxybenzoate

: 179872-39-0
4-amino-5-chloro-3-iodo-2-methoxybenzoic acid

Guidance literature:: With sodium hydroxide; In ethanol; Inert atmosphere;
DOI:10.1016/j.ejmech.2018.10.064

Reference yield: 73.0%

: 179872-38-9
4-acetylamino-5-chloro-3-iodo-2-methoxybenzoic acid

: 179872-39-0
4-amino-5-chloro-3-iodo-2-methoxybenzoic acid

Guidance literature:: With sodium hydroxide; In ethanol; for 16h; Heating;
DOI:10.1016/S0960-894X(96)00497-0

Reference yield:

: 4093-28-1
methyl 4-acetamido-2-hydroxybenzoate

: 179872-39-0
4-amino-5-chloro-3-iodo-2-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / SO₂Cl₂ / CHCl₃ / 3 h / 25 °C

2: 77 percent / NaI, chloramine-T / dimethylformamide / 1 h / 10 °C

3: 62 percent / K₂CO₃ / acetone / 2 h / Heating

4: 70 percent / NaOH / ethanol / 0.5 h / 80 °C

5: 73 percent / NaOH / ethanol / 16 h / Heating

With sodium hydroxide; sulfuryl dichloride; chloroamine-T; potassium carbonate; sodium iodide; In ethanol; chloroform; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0960-894X(96)00497-0