Fmoc-4-(phenoxy)-L-phenylalanine

Base Information

Chemical Name:Fmoc-4-(phenoxy)-L-phenylalanine
CAS No.:180414-93-1
Molecular Formula:C30H25NO5
Molecular Weight:479.532
Hs Code.:
DSSTox Substance ID:DTXSID70583810
Wikidata:Q82475410
Mol file:180414-93-1.mol

Synonyms:180414-93-1;Fmoc-4-(phenoxy)-L-phenylalanine;Fmoc-Tyr(Ph)-OH;L-Tyrosine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-phenyl-;(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(4-phenoxyphenyl)propanoic acid;(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(4-phenoxyphenyl)propanoic acid;(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-phenoxyphenyl)propanoic acid;N-Fmoc-O-Phenyl-L-Tyrosine;DTXSID70583810;MFCD11226820;AKOS027439346;AS-70729;CS-0439263;E70837;Fmoc-4-(phenoxy)-L-phenylalanine (Fmoc-L-Tyr(Ph)-OH);N-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-O-phenyl-L-tyrosine;(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-phenoxyphenyl)propanoicacid

Suppliers and Price of Fmoc-4-(phenoxy)-L-phenylalanine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of Fmoc-4-(phenoxy)-L-phenylalanine

Chemical Property:

XLogP3:6.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:9
Exact Mass:479.17327290
Heavy Atom Count:36
Complexity:707

Purity/Quality:: ≥ 99% (HPLC) ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)OC2=CC=C(C=C2)CC(C(=O)O)NC(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35
Isomeric SMILES:C1=CC=C(C=C1)OC2=CC=C(C=C2)C[C@@H](C(=O)O)NC(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35

Technology Process of Fmoc-4-(phenoxy)-L-phenylalanine

There total 4 articles about Fmoc-4-(phenoxy)-L-phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 150351-64-7
C₁₅H₁₅NO₃

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 180414-93-1
Fmoc-4-(phenoxy)-L-phenylalanine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1002/anie.201812348

Reference yield:

: C₂₄H₂₃NO₅

: 180414-93-1
Fmoc-4-(phenoxy)-L-phenylalanine

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogenchloride; hydrogen / methanol / 16 h / 20 °C

1.2: 5 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1002/anie.201812348

Reference yield:

: 98-80-6
phenylboronic acid

: 180414-93-1
Fmoc-4-(phenoxy)-L-phenylalanine

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper diacetate; pyridine / dichloromethane / 120 h / 25 °C / Molecular sieve

2.1: palladium 10% on activated carbon; hydrogenchloride; hydrogen / methanol / 16 h / 20 °C

2.2: 5 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

With pyridine; hydrogenchloride; palladium 10% on activated carbon; hydrogen; copper diacetate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1002/anie.201812348