Glycine, N-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-N-[(1S,2S) -2-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexyl]-, methyl ester

Base Information

Chemical Name:Glycine, N-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-N-[(1S,2S) -2-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexyl]-, methyl ester
CAS No.:180509-99-3
Molecular Formula:C21H32N4O7
Molecular Weight:452.508
Hs Code.:

Glycine,
N-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-N-[(1S,2S)
-2-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexyl]-, methyl ester

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Chemical Property of Glycine, N-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-N-[(1S,2S) -2-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexyl]-, methyl ester

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Technology Process of Glycine, N-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-N-[(1S,2S) -2-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexyl]-, methyl ester

There total 4 articles about Glycine, N-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-N-[(1S,2S) -2-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 20924-05-4
thymidyl acetic acid

: 180509-98-2
((1S,2S)-2-tert-Butoxycarbonylamino-cyclohexylamino)-acetic acid methyl ester

: 180509-99-3
{((1S,2S)-2-tert-Butoxycarbonylamino-cyclohexyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid methyl ester

Guidance literature:: With 3-hydroxy-3,4-dihydrobenzotriazine-4-one; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; for 4.5h; Ambient temperature;
DOI:10.1002/chem.19970030613

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 180509-99-3
{((1S,2S)-2-tert-Butoxycarbonylamino-cyclohexyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / CH₂Cl₂ / Ambient temperature

2: 70 percent / K₂CO₃ / dimethylformamide / 1 h / 0 °C

3: 72 percent / 3,4-dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine, DCC / dimethylformamide; CH₂Cl₂ / 4.5 h / Ambient temperature

With potassium carbonate; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.19970030613

Reference yield:

: 21436-03-3
(S,S)-1,2-diaminocyclohexane

: 180509-99-3
{((1S,2S)-2-tert-Butoxycarbonylamino-cyclohexyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / CH₂Cl₂ / Ambient temperature

2: 70 percent / K₂CO₃ / dimethylformamide / 1 h / 0 °C

3: 72 percent / 3,4-dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine, DCC / dimethylformamide; CH₂Cl₂ / 4.5 h / Ambient temperature

With potassium carbonate; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.19970030613