D-Glutamic acid, 4-(benzoylamino)-N-[(1,1-dimethylethoxy)carbonyl]-, dimethyl ester, (4S)-

Base Information

• Chemical Name: D-Glutamic acid, 4-(benzoylamino)-N-[(1,1-dimethylethoxy)carbonyl]-, dimethyl ester, (4S)-
• CAS No.: 180715-03-1
• Molecular Formula: C₁₉H₂₆N₂O₇
• Molecular Weight: 394.425
• Mol file: 180715-03-1.mol

Synonyms:

Chemical Property of D-Glutamic acid, 4-(benzoylamino)-N-[(1,1-dimethylethoxy)carbonyl]-, dimethyl ester, (4S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of D-Glutamic acid, 4-(benzoylamino)-N-[(1,1-dimethylethoxy)carbonyl]-, dimethyl ester, (4S)-

There total 4 articles about D-Glutamic acid, 4-(benzoylamino)-N-[(1,1-dimethylethoxy)carbonyl]-, dimethyl ester, (4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-2-Benzoylamino-4-tert-butoxycarbonylamino-5-hydroxy-pentanoic acid methyl ester → (2S,4R)-2-Benzoylamino-4-tert-butoxycarbonylamino-pentanedioic acid dimethyl ester (180715-03-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Jones' reagent / acetone / 0 °C

2: diethyl ether / Ambient temperature

With jones' reagent; In diethyl ether; acetone;

DOI:10.1016/S0957-4166(97)00044-X

Reference yield:

(R)-4-(2-Benzoylamino-2-methoxycarbonyl-ethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester → (2S,4R)-2-Benzoylamino-4-tert-butoxycarbonylamino-pentanedioic acid dimethyl ester (180715-03-1)

Guidance literature:

Multi-step reaction with 3 steps

1: camphorsulphonic acid / methanol / 20 h / Ambient temperature

2: Jones' reagent / acetone / 0 °C

3: diethyl ether / Ambient temperature

With jones' reagent; camphor-10-sulfonic acid; In methanol; diethyl ether; acetone;

DOI:10.1016/S0957-4166(97)00044-X

Reference yield:

(R)-4-((Z)-2-Benzoylamino-2-methoxycarbonyl-vinyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester → (2S,4R)-2-Benzoylamino-4-tert-butoxycarbonylamino-pentanedioic acid dimethyl ester (180715-03-1)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂ / propan-2-ol / 8 h / Ambient temperature

2: camphosulfonic acid / methanol

3: H₂SO₄, Cr₂O₃ / 0 °C

4: diethyl ether / Ambient temperature

With chromium(III) oxide; sulfuric acid; camphor-10-sulfonic acid; hydrogen; In methanol; diethyl ether; isopropyl alcohol;

DOI:10.1016/0957-4166(96)00179-6

upstream raw materials:

diazomethane

Downstream raw materials:

trans-3-amino-5-methoxycarbonylpyrrolidin-2-one