2-Fluoro-6-methyl-9-pentofuranosyl-9h-purine

Base Information

Chemical Name:2-Fluoro-6-methyl-9-pentofuranosyl-9h-purine
CAS No.:16032-21-6
Molecular Formula:C₁₁H₁₃FN₄O₄
Molecular Weight:284.247
Hs Code.:
NSC Number:111538
DSSTox Substance ID:DTXSID50296779
Mol file:16032-21-6.mol

Synonyms:16032-21-6;2-fluoro-6-methyl-9-pentofuranosyl-9h-purine;NSC111538;DTXSID50296779;NSC-111538

Suppliers and Price of 2-Fluoro-6-methyl-9-pentofuranosyl-9h-purine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of 2-Fluoro-6-methyl-9-pentofuranosyl-9h-purine

Chemical Property:

Vapor Pressure:6.2E-18mmHg at 25°C
Boiling Point:652.8°Cat760mmHg
Flash Point:348.6°C
Density:1.9g/cm³
XLogP3:0.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:2
Exact Mass:284.09208307
Heavy Atom Count:20
Complexity:365

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C2C(=NC(=N1)F)N(C=N2)C3C(C(C(O3)CO)O)O

Technology Process of 2-Fluoro-6-methyl-9-pentofuranosyl-9h-purine

There total 4 articles about 2-Fluoro-6-methyl-9-pentofuranosyl-9h-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 30747-23-0
N⁽²⁾,O(2'),O(3'),O(5')-tetraacetylguanosine

: 16032-21-6
2-fluoro-6-methyl-9-β-D-ribofuranosylpurine

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / triethylamine / CHCl₃ / 1.5 h / Ambient temperature

2: 1.) NaH / 1.)THF, rt; 2.) THF, rt, reflux 2.5 h

3: 51 percent / 1N NaOH / ethanol / 25 h / Ambient temperature

4: 1.) 48percent aqueous fluoboric acid; 2.) sodium nitrite / 1.) -15 deg C, 1 h; 2.) water, -15 deg C, 30 min

With sodium hydroxide; tetrafluoroboric acid; sodium hydride; triethylamine; sodium nitrite; In ethanol; chloroform;
DOI:10.1248/cpb.30.2583

Reference yield:

: 84017-51-6
2-acetamido-6-ethoxycarbonylmethyl-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine

: 16032-21-6
2-fluoro-6-methyl-9-β-D-ribofuranosylpurine

Guidance literature:: Multi-step reaction with 2 steps

1: 51 percent / 1N NaOH / ethanol / 25 h / Ambient temperature

2: 1.) 48percent aqueous fluoboric acid; 2.) sodium nitrite / 1.) -15 deg C, 1 h; 2.) water, -15 deg C, 30 min

With sodium hydroxide; tetrafluoroboric acid; sodium nitrite; In ethanol;
DOI:10.1248/cpb.30.2583

Reference yield:

: 84017-50-5
N⁽²⁾,O(2'),O(3'),O(5')-tetraacetyl-O⁽⁶⁾-p-toluenesulfonylguanosine

: 16032-21-6
2-fluoro-6-methyl-9-β-D-ribofuranosylpurine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.)THF, rt; 2.) THF, rt, reflux 2.5 h

2: 51 percent / 1N NaOH / ethanol / 25 h / Ambient temperature

3: 1.) 48percent aqueous fluoboric acid; 2.) sodium nitrite / 1.) -15 deg C, 1 h; 2.) water, -15 deg C, 30 min

With sodium hydroxide; tetrafluoroboric acid; sodium hydride; sodium nitrite; In ethanol;
DOI:10.1248/cpb.30.2583