2-Chloro-1-(4-chlorophenyl)ethanol

Base Information

• Chemical Name: 2-Chloro-1-(4-chlorophenyl)ethanol
• CAS No.: 6378-66-1
• Molecular Formula: C8H8 Cl2 O
• Molecular Weight: 191.057
• Hs Code.: 2906299090
• European Community (EC) Number: 228-954-5
• DSSTox Substance ID: DTXSID40980352
• Nikkaji Number: J206.984I
• Mol file: 6378-66-1.mol

Synonyms:2-chloro-1-(4-chlorophenyl)ethanol;6378-66-1;2-Chloro-1-(4-chloro-phenyl)-ethanol;EINECS 228-954-5;2-chloro-1-(4-chlorophenyl)ethan-1-ol;4-Chloro-alpha-(chloromethyl)benzyl alcohol;SCHEMBL3924286;p-chlorophenylchloromethylcarbinol;DTXSID40980352;1-(4-chlorophenyl)-2-chloroethanol;MFCD00462592;AKOS006272516;AS-37355;(+)-2-chloro-1-(4'-chlorophenyl)ethanol;(-)-2-chloro-1-(4'-chlorophenyl) ethanol;4-chloro-alpha-(chloromethyl)benzenemethanol;A8773;CS-0157552;EN300-295776

Chemical Property of 2-Chloro-1-(4-chlorophenyl)ethanol

Chemical Property:

• Vapor Pressure: 0.000679mmHg at 25°C
• Melting Point: 39-41 °C
• Boiling Point: 295.7°C at 760 mmHg
• PKA: 13.00±0.20(Predicted)
• Flash Point: 122.4°C
• PSA: 20.23000
• Density: 1.328g/cm³
• LogP: 2.61220
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 189.9952203
• Heavy Atom Count: 11
• Complexity: 111

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-1-(4-chlorophenyl)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C(CCl)O)Cl

Technology Process of 2-Chloro-1-(4-chlorophenyl)ethanol

There total 9 articles about 2-Chloro-1-(4-chlorophenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

Chloroiodomethane (593-71-5) + 4-chlorobenzaldehyde (104-88-1) → 2-chloro-1-(4-chlorophenyl)ethanol (6378-66-1)

Guidance literature:

Chloroiodomethane; With TurboGrignard; In tetrahydrofuran; at -20 ℃; for 0.000277778h; Flow reactor;

4-chlorobenzaldehyde; In tetrahydrofuran; at -20 ℃; for 0.000444444h; Flow reactor;

DOI:10.1021/acs.orglett.0c02725

Reference yield: 95.0%

p-chlorophenacyl chloride (937-20-2) → 2-chloro-1-(4-chlorophenyl)ethanol (6378-66-1)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; water; at 20 ℃; for 2h;

DOI:10.1021/jm800009r

Reference yield: 94.0%

4-Chlorostyrene oxide (2788-86-5) → 2-chloro-1-(4-chlorophenyl)ethanol (6378-66-1)

Guidance literature:

4-Chlorostyrene oxide; With β‐cyclodextrin; In water; acetone; at 60 ℃;

With thionyl chloride; In water; acetone; at 20 ℃; for 10h;

DOI:10.1080/00397910500182606

upstream raw materials:

2-chloroethanal

(4-chlorphenyl)magnesium bromide

aluminum isopropoxide

p-chlorophenacyl chloride

Downstream raw materials:

4-Chlorostyrene oxide

(E/Z)-1-chloro-4-(4-methylstyryl)benzene

1-phenyl-(4'-chloro)-1-fluoro-2-chloroethane

(RS)-3-(4-chlorophenyl)-3-hydroxypropionitrile