3β-Phenylaziridine

Base Information

• Chemical Name: 3β-Phenylaziridine
• CAS No.: 18142-08-0
• Molecular Formula: C8H9N
• Molecular Weight: 119.166
• Mol file: 18142-08-0.mol

Synonyms:(R)-2-phenylaziridine;(R)-2-Phenyl-aziridine;(S)-2-phenylaziridine;(R)(-)-2-phenyl-aziridine;2-phenylaziridine;

Chemical Property of 3β-Phenylaziridine

Chemical Property:

• PSA: 21.94000
• LogP: 1.65970

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3β-Phenylaziridine

There total 11 articles about 3β-Phenylaziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

D-2-phenylglycinol (56613-80-0) → (R)-(-)-2-phenylaziridine (18142-08-0)

Guidance literature:

D-2-phenylglycinol; With sulfuric acid; at 120 ℃;

With potassium hydroxide;

DOI:10.1016/S0957-4166(02)00312-9

Reference yield: 77.0%

methyllithium (917-54-4) + (+)-(SS,2R)-N-p-tolylsufinyl-2-phenylarizidine → (R)-2-phenylaziridine (18142-08-0) + (S)-methyl p-tolyl sulfoxide (5056-07-5)

Guidance literature:

In tetrahydrofuran; at -78 ℃;

DOI:10.1016/0040-4039(94)02234-3

Reference yield: 48.0%

(R)-1-((R)-(1S,2R,3S,4R)-3-Methoxy-4,7,7-trimethyl-bicyclo[2.2.1]heptane-2-sulfinyl)-2-phenyl-aziridine → (R)-(-)-2-phenylaziridine (18142-08-0)

Guidance literature:

With methyllithium; In tetrahydrofuran; diethyl ether; at -78 ℃; for 0.166667h;

DOI:10.1080/00397910008087125

upstream raw materials:

methyllithium

D-2-phenylglycinol

3-phenyl-2H-azirine

(R)-Styrene oxide

Downstream raw materials:

(R,R)-ethyl bis(2-phenyl-1-aziridinyl)phosphinylcarbamate

(R,R,R)-tris(2-phenyl-1-aziridinyl)phosphine oxide

(R,R)-ethyl bis(2-phenyl-1-aziridinyl)phosphinate

(R)-2-Phenyl-aziridine-1-carboxylic acid benzyl ester