Glycinamide-beta-carboline-3-carboxylate methyl ester

Base Information

Chemical Name:Glycinamide-beta-carboline-3-carboxylate methyl ester
CAS No.:100009-01-6
Molecular Formula:C₁₅H₁₃N₃O₃
Molecular Weight:283.287
Hs Code.:
DSSTox Substance ID:DTXSID00142858
Wikidata:Q83006428
Mol file:100009-01-6.mol

Synonyms:Gly-b-CCME;glycinamide-beta-carboline-3-carboxylate methyl ester

Suppliers and Price of Glycinamide-beta-carboline-3-carboxylate methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of Glycinamide-beta-carboline-3-carboxylate methyl ester

Chemical Property:

Vapor Pressure:2.58E-15mmHg at 25°C
Boiling Point:620.4°Cat760mmHg
Flash Point:329°C
PSA：84.08000
Density:1.374g/cm³
LogP:2.00980
XLogP3:1.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:283.09569129
Heavy Atom Count:21
Complexity:415

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)CNC(=O)C1=NC=C2C(=C1)C3=CC=CC=C3N2

Technology Process of Glycinamide-beta-carboline-3-carboxylate methyl ester

There total 6 articles about Glycinamide-beta-carboline-3-carboxylate methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 74214-63-4
β-carboline-3-carboxylic acid

: 616-34-2
methoxycarbonylmethylamine

: 100009-01-6
methyl 2-(9H-pyrido[3,4-b]indole-3-carboxamido)acetate

Guidance literature:: β-carboline-3-carboxylic acid; With 4-methyl-morpholine; chloroformic acid ethyl ester; In tetrahydrofuran; at 0 ℃; for 0.5h;

methoxycarbonylmethylamine; With triethylamine; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/acs.jmedchem.5b01052

Reference yield: 75.0%

: 74214-63-4
β-carboline-3-carboxylic acid

: 5680-79-5,883886-67-7
glycine ethyl ester hydrochloride

: 100009-01-6
methyl 2-(9H-pyrido[3,4-b]indole-3-carboxamido)acetate

Guidance literature:: With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1002/jps.2600740620

Reference yield:

: 69954-48-9
methyl 9H-β-carboline-3-carboxylate

: 100009-01-6
methyl 2-(9H-pyrido[3,4-b]indole-3-carboxamido)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / Pb(OAc)4 / acetic acid / 1 h

2: 96 percent / NaOH / ethanol; H₂O / 0.5 h / Heating

3: 75 percent / 1,1'-carbonyldiimidazole / dimethylformamide / Ambient temperature

With lead(IV) acetate; sodium hydroxide; 1,1'-carbonyldiimidazole; In ethanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1002/jps.2600740620