Technology Process of 1H-Indene, 3-[(1R,2R,5S)-5-methyl-2-(1-methylethyl)cyclohexyl]-
There total 1 articles about 1H-Indene, 3-[(1R,2R,5S)-5-methyl-2-(1-methylethyl)cyclohexyl]- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
n-butyllithium;
In
tetrahydrofuran; hexane;
byproducts: (pS)-(η4-NBD)(η5-1-neomenthylindenyl)Co(I), PPh3; BuLi (hexane) added under Ar to THF soln. of neomenthylindene at -78°C, warmed to room temp., stirred (2 h), cooled to -78°C, CoCl(PPh3)3 added, stirred for 2 h at room temp., NBD added, refluxed for 0.5 h; diastereoselectivity 74.2% de; cooled, filtd. through silica (THF), evapd., residue dried for 1 h underhigh vac., chromd. on a silica column (pentane eluted main diastereomer as the first fraction), eluate concd., kept at -78°C, crystals f iltd., dried in vacuo; elem. anal.;
DOI:10.1021/om030357m
- Guidance literature:
-
With
n-butyllithium;
In
tetrahydrofuran; hexane;
byproducts: (pS)-(η4-COD)(η5-1-neomenthylindenyl)Co(I), PPh3; BuLi (hexane) added under Ar to THF soln. of neomenthylindene at -78°C, warmed to room temp., stirred (2 h), cooled to -78°C, CoCl(PPh3)3 added, stirred for 2 h at room temp., COD added, refluxed for 0.5 h; diastereoselectivity 74.2% de; cooled, filtd. through silica (THF), evapd., residue dried for 1 h underhigh vac., chromd. on a silica column (pentane eluted main diastereomer as the first fraction), eluate concd., kept at -78°C, crystals f iltd., dried in vacuo; elem. anal.;
DOI:10.1021/om030357m
