N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide

Base Information

Chemical Name:N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide
CAS No.:182182-31-6
Molecular Formula:C13H15FN2O2
Molecular Weight:250.273
Hs Code.:
UNII:7H9ZFM4QC3
DSSTox Substance ID:DTXSID00436941
Mol file:182182-31-6.mol

Synonyms:182182-31-6;N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide;Acetamide, N-(8-amino-6-fluoro-1,2,3,4-tetrahydro-5-methyl-1-oxo-2-naphthalenyl)-;2-acetylamino-8-amino-6-fluoro-5-methyl-1-tetralone;N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydro-naphthalen-2-yl)-acetamide;7H9ZFM4QC3;SCHEMBL7165490;DTXSID00436941;SEFPQWAVZCZXTK-UHFFFAOYSA-N;EX-A4330;MFCD18827384;AKOS015841014;N-(8-amino-6-fluoro-5-methyl-1-oxo-3,4-dihydro-2H-naphthalen-2-yl)acetamide;AC-33802;AS-73855;CS-0040236;D72330;2-acetylamino-8-amino-6 -fluoro-5-methyl-l-tetralone;N-(8-Amino-6-fluoro-1,2,3,4-tetrahydro-5-methyl-1-oxo-2-naphthalenyl)acetamide

Suppliers and Price of N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 43 raw suppliers

Chemical Property of N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide

Chemical Property:

XLogP3:1.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:250.11175589
Heavy Atom Count:18
Complexity:361

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C=C(C2=C1CCC(C2=O)NC(=O)C)N)F
Use Description Acetamide, N-(8-amino-6-fluoro-1,2,3,4-tetrahydro-5-methyl-1-oxo-2-naphthalenyl)-, a specific chemical compound, serves diverse functions across various fields. In the realm of medicinal chemistry, it plays a crucial role as a potential building block or intermediate in the synthesis of compounds with potential pharmaceutical applications, contributing to drug discovery and development efforts. In organic synthesis, Acetamide, N-(8-amino-6-fluoro-1,2,3,4-tetrahydro-5-methyl-1-oxo-2-naphthalenyl)- acts as a versatile reagent, enabling the creation of complex molecular structures for research purposes. Additionally, in the field of chemical research, it may be employed to investigate new reactions or explore new chemical transformations. Its applications in medicinal chemistry, organic synthesis, and chemical research underscore its significance in driving innovation, scientific exploration, and potential medical breakthroughs across these different domains.

Technology Process of N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide

There total 6 articles about N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 143655-70-3
C₁₅H₁₇FN₂O₃

: 182182-31-6
2-Acetylamino-8-amino-6-fluoro-5-methyl-1-tetralone

Guidance literature:: With hydrogenchloride; In methanol; at 60 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: C₁₃H₁₆FNO₂

: 182182-31-6
2-Acetylamino-8-amino-6-fluoro-5-methyl-1-tetralone

Guidance literature:: Multi-step reaction with 3 steps

1.1: dipotassium peroxodisulfate / acetonitrile; water / 8 h / 30 °C

2.1: potassium tert-butylate / tetrahydrofuran; tert-butyl alcohol / 0.17 h / 5 °C

2.2: 1 h

3.1: hydrogenchloride / methanol / 0.5 h / 60 °C / Inert atmosphere

With hydrogenchloride; dipotassium peroxodisulfate; potassium tert-butylate; In tetrahydrofuran; methanol; water; acetonitrile; tert-butyl alcohol;

Reference yield:

: 452-77-7
3-fluoro-4-methyl-phenylamine

: 182182-31-6
2-Acetylamino-8-amino-6-fluoro-5-methyl-1-tetralone

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / 0.5 h / 10 °C

2.1: bromine; acetic acid; sodium acetate / 2 h / 60 - 80 °C

3.1: n-butyllithium / tetrahydrofuran / 1.5 h / -78 °C

3.2: 1 h / -78 - 20 °C

4.1: dipotassium peroxodisulfate / acetonitrile; water / 8 h / 30 °C

5.1: potassium tert-butylate / tetrahydrofuran; tert-butyl alcohol / 0.17 h / 5 °C

5.2: 1 h

6.1: hydrogenchloride / methanol / 0.5 h / 60 °C / Inert atmosphere

With hydrogenchloride; dipotassium peroxodisulfate; n-butyllithium; sulfuric acid; potassium tert-butylate; bromine; sodium acetate; acetic acid; In tetrahydrofuran; methanol; water; acetonitrile; tert-butyl alcohol;