Chemical Property of 2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol
Chemical Property:
- Vapor Pressure:5.84E-14mmHg at 25°C
- Melting Point:140-142°C
- Boiling Point:572.8oC at 760 mmHg
- Flash Point:300.2oC
- PSA：85.73000
- Density:1.3g/cm3
- LogP:2.82400
- Storage Temp.:-20°C Freezer
- Solubility.:insoluble in H2O; insoluble in EtOH; ≥51 mg/mL in DMSO
- XLogP3:2.8
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:10
- Exact Mass:379.15320616
- Heavy Atom Count:28
- Complexity:511
- Purity/Quality:
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99%, *data from raw suppliers
OSI-420,FreeBase(DesmethylErlotinib) *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:COCCOC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCO
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Description
Desmethyl erlotinib is a metabolite of erlotinib . Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity (IC50 = 2.5 μM). This inhibits tumor growth in human head and neck carcinoma HN5 tumor xenografts in mice with an ED50 value of 9 mg/kg. Erlotinib also suppresses cyclin-dependent kinase 2 (Cdk2) activity in breast cancer cells (IC50 = 4.6 μM) and JAK2 mutant JAK2V617F positive hematopoietic progenitor cells (IC50 = 5 μM), which is associated with polycythemia vera, idiopathic myelofibrosis, and essential thrombocythemia. Formulations containing erlotinib have been used to treat certain forms of cancer, including non-small cell lung cancer.
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Uses
A metabolite of Erlotinib (E625000), an anti cancer agent.
