2,6-DIMETHYL-4-(3-NITRO-PHENYL)-PYRIDINE-3,5-DICARBOXYLIC ACID 3-ETHYL ESTER 5-METHYL ESTER

Base Information

• Chemical Name: 2,6-DIMETHYL-4-(3-NITRO-PHENYL)-PYRIDINE-3,5-DICARBOXYLIC ACID 3-ETHYL ESTER 5-METHYL ESTER
• CAS No.: 89267-41-4
• Molecular Formula: C18H18 N2 O6
• Molecular Weight: 358.351
• Mol file: 89267-41-4.mol

Synonyms:3,5-Pyridinedicarboxylicacid, 2,6-dimethyl-4-(3-nitrophenyl)-, ethyl methyl ester (9CI); BAY-m 4786;Dehydronitrendipine

Chemical Property of 2,6-DIMETHYL-4-(3-NITRO-PHENYL)-PYRIDINE-3,5-DICARBOXYLIC ACID 3-ETHYL ESTER 5-METHYL ESTER

Chemical Property:

• Vapor Pressure: 7.69E-09mmHg at 25°C
• Melting Point: 59-61℃
• Boiling Point: 465.4°C at 760 mmHg
• Flash Point: 235.3°C
• PSA: 111.31000
• Density: 1.259g/cm³
• LogP: 3.76010
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99%min. ^*data from raw suppliers

Nitrendipine impurity A European Pharmacopoeia (EP) Reference Standard ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Dehydronitrendipine is a derivative of Nitrendipine (N490150), a dihydropyridine calcium channel blocker. Nitrendipine is used in the treatment of primary (essential) hypertension to decrease blood pressure. Dehydronitrendipine is a derivative of Nitrendipine (N490150), a dihydropyridine calcium channel blocker. Nitrendipine is used in the treatment of primary (essential) hypertension to decrease blood pressure. Antihypertensive.

Technology Process of 2,6-DIMETHYL-4-(3-NITRO-PHENYL)-PYRIDINE-3,5-DICARBOXYLIC ACID 3-ETHYL ESTER 5-METHYL ESTER

There total 1 articles about 2,6-DIMETHYL-4-(3-NITRO-PHENYL)-PYRIDINE-3,5-DICARBOXYLIC ACID 3-ETHYL ESTER 5-METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester (39562-70-4) → (+/-)-Oxidized Nitrendipine (89267-41-4)

Guidance literature:

With ammonium cerium(IV) nitrate; In water; acetone; for 0.166667h; Ambient temperature;

DOI:10.1055/s-1990-26982

upstream raw materials:

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

Refernces

• 1、 Lu, Zheng,Yang, Yong-Qing,Li, Hong-Xia. "Photoinduced Aromatization of Dihydropyridines". supporting information. p. 4221 - 4227. Retrieved 2016/11/26.
• 2、 Filipan-Litvi?, Mirela,Litvi?, Mladen,Vinkovi?, Vladimir. "An efficient, metal-free, room temperature aromatization of Hantzsch-1,4-dihydropyridines with urea-hydrogen peroxide adduct, catalyzed by molecular iodine". . p. 5649 - 5656. Retrieved 2008/09/21.