4,5-DIMETHOXY-2-NITROTOLUENE

Base Information

• Chemical Name: 4,5-DIMETHOXY-2-NITROTOLUENE
• CAS No.: 7509-11-7
• Molecular Formula: C39H11NO4
• Molecular Weight: 197.191
• Hs Code.: 2909309090
• Mol file: 7509-11-7.mol

Synonyms:Homoveratrole,5-nitro- (4CI);Toluene, 4,5-dimethoxy-2-nitro- (7CI);Veratrole,4-methyl-5-nitro- (6CI);1,2-Dimethoxy-4-methyl-5-nitrobenzene;4,5-Dimethoxy-2-nitrotoluene;5-Nitrohomoveratrole;NSC 105304;NSC 407251;

Chemical Property of 4,5-DIMETHOXY-2-NITROTOLUENE

Chemical Property:

• Vapor Pressure: 0.000704mmHg at 25°C
• Melting Point: 119-120°C
• Refractive Index: 1.528
• Boiling Point: 317.7 °C at 760 mmHg
• Flash Point: 147.3 °C
• PSA: 64.28000
• Density: 1.191g/cm³
• LogP: 2.44360
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4,5-Dimethoxy-2-nitrotoluene 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,5-DIMETHOXY-2-NITROTOLUENE

There total 31 articles about 4,5-DIMETHOXY-2-NITROTOLUENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

1,2-dimethoxy-4-methylbenzene (494-99-5) → 1,2-dimethoxy-4-methyl-5-nitrobenzene (7509-11-7)

Guidance literature:

With nitric acid; acetic acid; at 20 ℃; for 0.5h;

DOI:10.1021/op100185x

Reference yield: 54.0%

(4,5-dimethoxy-2-methylphenyl)-(3,4-dimethoxyphenyl)-methane (102415-87-2) → 1,2-dimethoxy-4-methyl-5-nitrobenzene (7509-11-7) + 3,4-dimethoxy-benzaldehyde (120-14-9)

Guidance literature:

With ammonium cerium(IV) nitrate; acetic acid;

DOI:10.1016/S0040-4039(02)00743-8

Reference yield: 10.0%

3,4-dimethoxynitrobenzene (709-09-1) + dimethyl sulfoxide (67-68-5,8070-53-9) → 1,2-dimethoxy-4-methyl-5-nitrobenzene (7509-11-7) + 5-nitroguaiacol (636-93-1) + 1,2-dimethyoxy-3-methyl-4-nitrobenzene (82209-17-4)

Guidance literature:

With tetrabutyl ammonium fluoride; In dimethyl sulfoxide; for 2h; Irradiation;

DOI:10.1139/v98-044

upstream raw materials:

1,2-dimethoxy-4-methylbenzene

1-chloro-2-methoxy-5-methyl-4-nitrobenzene

sodium methylate

1-bromo-4,5-dimethoxy-2-methylbenzene

Downstream raw materials:

2-methoxy-5-methyl-4-nitro-phenol

trans-β-dimethylamino-4,5-dimethoxy-2-nitrostyrene

3,4-dimethoxy-6-methyl-o-phenylenediamine

4,5-dimethoxy-N,2-dimethylaniline

Refernces

• 1、 Reimann, Eberhard,Hertel, Rainer,Krauss, Juergen. "Synthesis of 6-methyl-8H-dibenzo[a,g]quinolizin-8-imines via Reissert compounds". experimental part. p. 673 - 684. Retrieved 2009/07/18.
• 2、 Lapa,Tolkachev. "Fragmentation of nitro(bromo)-substituted methylpapaverinium iodides under Kost-Sagitullin reaction conditions". . p. 377 - 378. Retrieved 2007/10/03.