1,7-Naphthyridine-6-carboxamide, N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-7,8-dihydro-7-[(3R)-4-hydroxy- 3-methylbutyl]-5-(4-methylphenyl)-8-oxo-

Base Information

Chemical Name:1,7-Naphthyridine-6-carboxamide, N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-7,8-dihydro-7-[(3R)-4-hydroxy- 3-methylbutyl]-5-(4-methylphenyl)-8-oxo-
CAS No.:183551-02-2
Molecular Formula:C30H27F6N3O3
Molecular Weight:591.553
Hs Code.:

1,7-Naphthyridine-6-carboxamide,
N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-7,8-dihydro-7-[(3R)-4-hydroxy-
3-methylbutyl]-5-(4-methylphenyl)-8-oxo-

Synonyms:

Suppliers and Price of 1,7-Naphthyridine-6-carboxamide, N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-7,8-dihydro-7-[(3R)-4-hydroxy- 3-methylbutyl]-5-(4-methylphenyl)-8-oxo-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1,7-Naphthyridine-6-carboxamide, N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-7,8-dihydro-7-[(3R)-4-hydroxy- 3-methylbutyl]-5-(4-methylphenyl)-8-oxo-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1,7-Naphthyridine-6-carboxamide, N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-7,8-dihydro-7-[(3R)-4-hydroxy- 3-methylbutyl]-5-(4-methylphenyl)-8-oxo-

There total 12 articles about 1,7-Naphthyridine-6-carboxamide, N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-7,8-dihydro-7-[(3R)-4-hydroxy- 3-methylbutyl]-5-(4-methylphenyl)-8-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 217099-10-0
7-[(R)-3-Methyl-4-(tetrahydro-pyran-2-yloxy)-butyl]-8-oxo-5-p-tolyl-7,8-dihydro-[1,7]naphthyridine-6-carboxylic acid 3,5-bis-trifluoromethyl-benzylamide

: 183551-02-2
(R)-N-[3,5-bis(trifluoromethyl)benzyl]-7,8-dihydro-7-(4-hydroxy-3-methylbutyl)-5-(4-methylphenyl)-8-oxo-1,7-naphthyridine-6-carboxamide

Guidance literature:: With toluene-4-sulfonic acid; In methanol; for 0.5h; Ambient temperature;
DOI:10.1039/a805333b

Reference yield:

: 183550-78-9
5-(4-methylphenyl)-8-oxo-8H-pyrano[3,4-b]pyridine-6-carboxylic acid

: 183551-02-2
(R)-N-[3,5-bis(trifluoromethyl)benzyl]-7,8-dihydro-7-(4-hydroxy-3-methylbutyl)-5-(4-methylphenyl)-8-oxo-1,7-naphthyridine-6-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride, DMF / 1,2-dichloro-ethane; tetrahydrofuran / 1.5 h / Heating

2.1: Et₃N / tetrahydrofuran / 0.5 h / 20 °C

3.1: tetrahydrofuran; methanol / 16 h / 20 °C

3.2: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile; toluene / 1 h / Heating

4.1: p-toluenesulfonic acid monohydrate / methanol / 0.5 h / 20 °C

With thionyl chloride; toluene-4-sulfonic acid; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; 1,2-dichloro-ethane; 1.1: Chlorination / 2.1: amidation / 3.1: Condensation / 3.2: Dehydration / 4.1: Hydrolysis;
DOI:10.1021/jm990220r

Reference yield:

: 183550-80-3
N-[3,5-bis(trifluoromethyl)benzyl]-5-(4-methylphenyl)-8-oxo-8H-pyrano[3,4-b]pyridine-6-carboxamide

: 183551-02-2
(R)-N-[3,5-bis(trifluoromethyl)benzyl]-7,8-dihydro-7-(4-hydroxy-3-methylbutyl)-5-(4-methylphenyl)-8-oxo-1,7-naphthyridine-6-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran; methanol / 16 h / 20 °C

1.2: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile; toluene / 1 h / Heating

2.1: p-toluenesulfonic acid monohydrate / methanol / 0.5 h / 20 °C

With toluene-4-sulfonic acid; In tetrahydrofuran; methanol; 1.1: Condensation / 1.2: Dehydration / 2.1: Hydrolysis;
DOI:10.1021/jm990220r