6-Nitrofluorescein diacetate

Base Information

Chemical Name:6-Nitrofluorescein diacetate
CAS No.:53299-21-1
Deprecated CAS:15010-94-3,195977-40-3
Molecular Formula:C24H15 N O9
Molecular Weight:461.384
Hs Code.:2932999099
DSSTox Substance ID:DTXSID60886044
Nikkaji Number:J380.368F
Wikidata:Q82864768
Mol file:53299-21-1.mol

Synonyms:6-Nitrofluorescein diacetate;53299-21-1;(6'-acetyloxy-6-nitro-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl) acetate;3',6'-Bis(acetyloxy)-6-nitrospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one;Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-bis(acetyloxy)-6-nitro-;Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-bis(acetyloxy)-6-nitro-;DTXSID60886044;AS-82954;FT-0672784;3,6-Diacetoxy-6'-nitrospiro[9H-xanthene-9,1'(3'H)-isobenzofuran]-3'-one;6-Nitro-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl diacetate;6-Nitro-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyldiacetate

Suppliers and Price of 6-Nitrofluorescein diacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-NitrofluoresceinDiacetate
2.5g
$ 155.00

American Custom Chemicals Corporation
6-NITROFLUORESCEIN DIACETATE 95.00%
2.5G
$ 300.00

Total 3 raw suppliers

Chemical Property of 6-Nitrofluorescein diacetate

Chemical Property:

Boiling Point:674.5±55.0 °C(Predicted)
PSA：133.95000
Density:1.56±0.1 g/cm3(Predicted)
LogP:4.53660
Solubility.:Chloroform, Dichloromethane, Methanol
XLogP3:3.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:4
Exact Mass:461.07468106
Heavy Atom Count:34
Complexity:829

Purity/Quality:

99% ^*data from raw suppliers

6-NitrofluoresceinDiacetate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)OC1=CC2=C(C=C1)C3(C4=C(O2)C=C(C=C4)OC(=O)C)C5=C(C=CC(=C5)[N+](=O)[O-])C(=O)O3
Uses Intermediate for the synthesis of 6-aminofluorescein and fluorescein 6-isothiocyanate Intermediate for the synthesis of 6-aminofluorescein and fluorescein 6-isothiocyanate.

Technology Process of 6-Nitrofluorescein diacetate

There total 3 articles about 6-Nitrofluorescein diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 610-27-5
4-nitrophthalic acid

: 108-24-7
acetic anhydride

: 120-80-9,19481-10-8,37349-32-9
benzene-1,2-diol

: 14926-29-5
3',6'-bis(acetyloxy)-5-nitrospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one

: 53299-21-1
3',6'-bis(acetyloxy)-4-nitrospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one

Guidance literature:: 4-nitrophthalic acid; benzene-1,2-diol; at 180 - 190 ℃; for 3h;

With hydrogenchloride; for 1h; Heating;

acetic anhydride; for 1h; Heating;
DOI:10.1002/hlca.200390186

Reference yield:

: 5466-84-2
4-nitrophthalic anhydride

: 108-24-7
acetic anhydride

: 108-46-3
recorcinol

: 14926-29-5
3',6'-bis(acetyloxy)-5-nitrospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one

: 53299-21-1
3',6'-bis(acetyloxy)-4-nitrospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one

Guidance literature:: 4-nitrophthalic anhydride; recorcinol; With zinc(II) chloride; at 180 ℃; for 2h;

acetic anhydride; With pyridine; at 20 ℃; for 19h;
DOI:10.1016/j.saa.2016.06.021