Phosphonic acid, [[[2-[bis(4-methoxyphenyl)phenylmethoxy]ethyl][(3,4-dihydro-5-methyl-2, 4-dioxo-1(2H)-pyrimidinyl)acetyl]amino]methyl]-, mono[(4-methoxy-1-oxido-2-pyridinyl)methyl] ester

Base Information

Chemical Name:Phosphonic acid, [[[2-[bis(4-methoxyphenyl)phenylmethoxy]ethyl][(3,4-dihydro-5-methyl-2, 4-dioxo-1(2H)-pyrimidinyl)acetyl]amino]methyl]-, mono[(4-methoxy-1-oxido-2-pyridinyl)methyl] ester
CAS No.:184159-53-3
Molecular Formula:C38H41N4O11P
Molecular Weight:760.737
Hs Code.:

Phosphonic acid,
[[[2-[bis(4-methoxyphenyl)phenylmethoxy]ethyl][(3,4-dihydro-5-methyl-2,
4-dioxo-1(2H)-pyrimidinyl)acetyl]amino]methyl]-,
mono[(4-methoxy-1-oxido-2-pyridinyl)methyl] ester

Synonyms:

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Chemical Property of Phosphonic acid, [[[2-[bis(4-methoxyphenyl)phenylmethoxy]ethyl][(3,4-dihydro-5-methyl-2, 4-dioxo-1(2H)-pyrimidinyl)acetyl]amino]methyl]-, mono[(4-methoxy-1-oxido-2-pyridinyl)methyl] ester

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Technology Process of Phosphonic acid, [[[2-[bis(4-methoxyphenyl)phenylmethoxy]ethyl][(3,4-dihydro-5-methyl-2, 4-dioxo-1(2H)-pyrimidinyl)acetyl]amino]methyl]-, mono[(4-methoxy-1-oxido-2-pyridinyl)methyl] ester

There total 8 articles about Phosphonic acid, [[[2-[bis(4-methoxyphenyl)phenylmethoxy]ethyl][(3,4-dihydro-5-methyl-2, 4-dioxo-1(2H)-pyrimidinyl)acetyl]amino]methyl]-, mono[(4-methoxy-1-oxido-2-pyridinyl)methyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 184159-50-0
({{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid 4-methoxy-1-oxy-pyridin-2-ylmethyl ester phenyl ester

: 184159-53-3
({{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid mono-(4-methoxy-1-oxy-pyridin-2-ylmethyl) ester

Guidance literature:: With water; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; for 0.5h; Yield given;
DOI:10.1016/0040-4039(96)01750-9

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 184159-53-3
({{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid mono-(4-methoxy-1-oxy-pyridin-2-ylmethyl) ester

Guidance literature:: Multi-step reaction with 9 steps

1: pyridine

2: hydrazine

3: ethyl acetate / 0.25 h

4: toluene / 2 h / 75 °C

5: N-methyl-morpholine / toluene

6: 75 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / dimethylformamide / 1 h / 75 °C

7: 1,8-diazabicyclo<5.4.0>undec-7-ene, H₂O / acetonitrile / 0.25 h / 20 °C

8: 2,4,6-triisopropylbenzenesulfonyl chloride, 4-methoxy-1-oxido-pyridine / acetonitrile / 0.5 h

9: 1,8-diazabicyclo<5.4.0>undec-7-ene, H₂O / acetonitrile / 0.5 h

With 4-methyl-morpholine; 4-methoxypyridine N-oxide; 2,4,6-triisopropylphenylsulfonyl chloride; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; hydrazine; In pyridine; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/0040-4039(96)01750-9

Reference yield:

: 153765-10-7
2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethanamine

: 184159-53-3
({{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid mono-(4-methoxy-1-oxy-pyridin-2-ylmethyl) ester

Guidance literature:: Multi-step reaction with 7 steps

1: ethyl acetate / 0.25 h

2: toluene / 2 h / 75 °C

3: N-methyl-morpholine / toluene

4: 75 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / dimethylformamide / 1 h / 75 °C

5: 1,8-diazabicyclo<5.4.0>undec-7-ene, H₂O / acetonitrile / 0.25 h / 20 °C

6: 2,4,6-triisopropylbenzenesulfonyl chloride, 4-methoxy-1-oxido-pyridine / acetonitrile / 0.5 h

7: 1,8-diazabicyclo<5.4.0>undec-7-ene, H₂O / acetonitrile / 0.5 h

With 4-methyl-morpholine; 4-methoxypyridine N-oxide; 2,4,6-triisopropylphenylsulfonyl chloride; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/0040-4039(96)01750-9