10,11-methylenedioxy-20-camptothecin

Base Information

• Chemical Name: 10,11-methylenedioxy-20-camptothecin
• CAS No.: 104155-89-7
• Molecular Formula: C₂₁H₁₆N₂O₆
• Molecular Weight: 392.368
• Mol file: 104155-89-7.mol

Synonyms:10H-1,3-Dioxolo[4,5-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-8,11(7H,13H)-dione,7-ethyl-7-hydroxy-, (?à)-; (?à)-10,11-(Methylenedioxy)camptothecin;NSC 634724

Chemical Property of 10,11-methylenedioxy-20-camptothecin

Chemical Property:

• Vapor Pressure: 7.11E-28mmHg at 25°C
• Boiling Point: 812.1°Cat760mmHg
• Flash Point: 445°C
• PSA: 99.88000
• Density: 1.64g/cm³
• LogP: 1.80830

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 10,11-methylenedioxy-20-camptothecin

There total 2 articles about 10,11-methylenedioxy-20-camptothecin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione (102978-40-5) + 6-amino-benzo[1,3]dioxole-5-carbaldehyde (23126-68-3) → 10,11-(methylenedioxy)-(20RS)-camptothecin (104155-89-7)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 8h; Heating;

DOI:10.1021/jm00161a035

Reference yield:

→ 10,11-(methylenedioxy)-(20RS)-camptothecin (104155-89-7)

Guidance literature:

upstream raw materials:

4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

6-amino-benzo[1,3]dioxole-5-carbaldehyde

Refernces

• 1、 Wani,Nicholas,Wall. "Plant antitumor agents. 23. Synthesis and antileukemic activity of camptothecin analogues". . p. 2358 - 2363. Retrieved 2007/10/02.