2-benzyl-6-methylpyrimidin-4(1H)-one

Base Information

• Chemical Name: 2-benzyl-6-methylpyrimidin-4(1H)-one
• CAS No.: 16673-85-1
• Molecular Formula: C12H12 N2 O
• Molecular Weight: 200.2365
• Mol file: 16673-85-1.mol

Synonyms:4(1H)-Pyrimidinone,6-methyl-2-(phenylmethyl)- (9CI); 4(3H)-Pyrimidinone, 2-benzyl-6-methyl- (8CI);NSC 246043

Chemical Property of 2-benzyl-6-methylpyrimidin-4(1H)-one

Chemical Property:

• Vapor Pressure: 8.42E-05mmHg at 25°C
• Boiling Point: 340.7°Cat760mmHg
• Flash Point: 159.9°C
• Density: 1.14g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-benzyl-6-methylpyrimidin-4(1H)-one

There total 7 articles about 2-benzyl-6-methylpyrimidin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

phenylacetonitrile (140-29-4) + β-aminocrotonamide (64163-94-6) → 2-benzyl-6-methyl-4(3H)-pyrimidinone (16673-85-1) + 6-amino-4-methyl-5-phenyl-2(1H)-pyridone

Guidance literature:

With sodium methylate; In methanol; Heating;

Reference yield:

phenylacetonitrile (140-29-4) → 2-benzyl-6-methyl-4(3H)-pyrimidinone (16673-85-1)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether / 12 h / 15 - 20 °C

2: 15percent ethanolic ammonia / 20 h / 20 - 25 °C

3: 2.8 g / ethanolic sodium hydroxide / ethanol / 40 h / Heating

With sodium hydroxide; ammonia; In diethyl ether; ethanol;

DOI:10.1071/CH9850825

Reference yield:

methyl phenylacetimidate hydrochloride → 2-benzyl-6-methyl-4(3H)-pyrimidinone (16673-85-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 15percent ethanolic ammonia / 20 h / 20 - 25 °C

2: 2.8 g / ethanolic sodium hydroxide / ethanol / 40 h / Heating

With sodium hydroxide; ammonia; In ethanol;

DOI:10.1071/CH9850825

upstream raw materials:

2-phenylacetamidine hydrochloride

ethyl acetoacetate

phenylacetonitrile

β-aminocrotonamide

Downstream raw materials:

4-[2-[2-benzyl-4-methyl-6-oxo-1,6-dihydropyrimidin-1-yl]ethoxy]benzaldehyde

2-benzyl-4-methyl-6-chloropyrimidine

2-benzyl-4-methyl-6-<α-(4-methyl-6-chloro-2-pyrimidinyl)benzyl>pyrimidine

4-[2-[4-methyl-2-propyl-6-oxo-1,6-dihydropyrimidin-1-yl]ethoxy]benzaldehyde