tert-butyl [(2S,3R)-4-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-[4-(2-methoxyethoxy)phenyl]butyl}amino)-3-hydroxy-1-phenylbutan-2-yl]carbamate

Base Information

Chemical Name:tert-butyl [(2S,3R)-4-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-[4-(2-methoxyethoxy)phenyl]butyl}amino)-3-hydroxy-1-phenylbutan-2-yl]carbamate
CAS No.:162539-95-9
Molecular Formula:C₃₃H₅₁N₃O₈
Molecular Weight:617.783
Hs Code.:
Mol file:162539-95-9.mol

tert-butyl [(2S,3R)-4-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-[4-(2-methoxyethoxy)phenyl]butyl}amino)-3-hydroxy-1-phenylbutan-2-yl]carbamate

Synonyms:12-Oxa-2,6,10-triazatetradecanoicacid,4,8-dihydroxy-3-[[4-(2-methoxyethoxy)phenyl]methyl]-13,13-dimethyl-11-oxo-9-(phenylmethyl)-,1,1-dimethylethyl ester, [3S-(3R*,4S*,8S*,9R*)]-

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Chemical Property of tert-butyl [(2S,3R)-4-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-[4-(2-methoxyethoxy)phenyl]butyl}amino)-3-hydroxy-1-phenylbutan-2-yl]carbamate

Chemical Property:

Vapor Pressure:4.3E-24mmHg at 25°C
Boiling Point:757.2°Cat760mmHg
Flash Point:411.7°C
PSA：154.59000
Density:1.143g/cm³
LogP:4.39470

Purity/Quality:

Safty Information:

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Technology Process of tert-butyl [(2S,3R)-4-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-[4-(2-methoxyethoxy)phenyl]butyl}amino)-3-hydroxy-1-phenylbutan-2-yl]carbamate

There total 17 articles about tert-butyl [(2S,3R)-4-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-[4-(2-methoxyethoxy)phenyl]butyl}amino)-3-hydroxy-1-phenylbutan-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 86827-18-1,92455-53-3,16677-29-5
N-benzyloxycarbonyl-O-benzyl-L-tyrosine

: 162539-95-9
{(S)-3-((S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-2-hydroxy-1-[4-(2-methoxy-ethoxy)-benzyl]-propyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 14 steps

1: 4-methylmorpholine / tetrahydrofuran

2: tetrahydrofuran; diethyl ether / 0 °C

3: HCl / dioxane / 0 °C

4: NaBH₄

5: KOH / ethanol

6: methanol / 50 °C

7: 92 percent / (i-Pr)2NEt / dimethylformamide / 2 h / 0 °C

8: H₂, 20percent Pd(OH)2/C / ethanol

9: Et₃N / methanol / 4 h

10: 98 percent / p-TsOH / benzene / 3 h / Heating

11: 84 percent / diethyl azodicarboxylate, Ph₃P / tetrahydrofuran / Ambient temperature

12: 98percent HCOOH / 0.33 h / 5 °C

13: Et₃N / methanol

14: Bu₄NF / tetrahydrofuran / 50 °C

With 4-methyl-morpholine; hydrogenchloride; palladium dihydroxide; potassium hydroxide; sodium tetrahydroborate; formic acid; tetrabutyl ammonium fluoride; hydrogen; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm950717a

Reference yield:

: {(S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-[4-(2-methoxy-ethoxy)-phenyl]-butyl}-((S)-3-tert-butoxycarbonylamino-2-hydroxy-4-phenyl-butyl)-carbamic acid 2-trimethylsilanyl-ethyl ester

: 162539-95-9
{(S)-3-((S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-2-hydroxy-1-[4-(2-methoxy-ethoxy)-benzyl]-propyl}-carbamic acid tert-butyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 50 ℃; Yield given;
DOI:10.1021/jm950717a

Reference yield:

: 220871-52-3
1(R,S)-<1'-(S)-<(tert-butyloxycarbonyl)amino>-2-phenylethyl>oxirane

: 162539-95-9
{(S)-3-((S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-2-hydroxy-1-[4-(2-methoxy-ethoxy)-benzyl]-propyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 63 percent / NH₃, NH₄OH / ethanol / Ambient temperature

2: methanol / 50 °C

3: 92 percent / (i-Pr)2NEt / dimethylformamide / 2 h / 0 °C

4: H₂, 20percent Pd(OH)2/C / ethanol

5: Et₃N / methanol / 4 h

6: 98 percent / p-TsOH / benzene / 3 h / Heating

7: 84 percent / diethyl azodicarboxylate, Ph₃P / tetrahydrofuran / Ambient temperature

8: 98percent HCOOH / 0.33 h / 5 °C

9: Et₃N / methanol

10: Bu₄NF / tetrahydrofuran / 50 °C

With palladium dihydroxide; ammonium hydroxide; formic acid; tetrabutyl ammonium fluoride; hydrogen; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm950717a