2-Piperidinone, 6-ethoxy-1-[(4-methylphenyl)sulfonyl]-

Base Information

Chemical Name:2-Piperidinone, 6-ethoxy-1-[(4-methylphenyl)sulfonyl]-
CAS No.:184637-78-3
Molecular Formula:C14H19NO4S
Molecular Weight:297.375
Hs Code.:
DSSTox Substance ID:DTXSID70454798
Nikkaji Number:J782.014C
Mol file:184637-78-3.mol

Synonyms:184637-78-3;2-Piperidinone, 6-ethoxy-1-[(4-methylphenyl)sulfonyl]-;DTXSID70454798;1-Tosyl-6-ethoxypiperidin-2-one

Suppliers and Price of 2-Piperidinone, 6-ethoxy-1-[(4-methylphenyl)sulfonyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 2-Piperidinone, 6-ethoxy-1-[(4-methylphenyl)sulfonyl]-

Chemical Property:

XLogP3:2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:297.10347926
Heavy Atom Count:20
Complexity:435

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC1CCCC(=O)N1S(=O)(=O)C2=CC=C(C=C2)C

Technology Process of 2-Piperidinone, 6-ethoxy-1-[(4-methylphenyl)sulfonyl]-

There total 2 articles about 2-Piperidinone, 6-ethoxy-1-[(4-methylphenyl)sulfonyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 39662-64-1
6-ethoxypiperidin-2-one

: 98-59-9
p-toluenesulfonyl chloride

: 184637-78-3
6-ethoxy-1-(toluene-4-sulfonyl)-piperidin-2-one

Guidance literature:: 6-ethoxypiperidin-2-one; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

p-toluenesulfonyl chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 19h;
DOI:10.1021/jo0493572

Reference yield:

: 1121-89-7
piperidine-2,6-dione

: 184637-78-3
6-ethoxy-1-(toluene-4-sulfonyl)-piperidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 72 percent / NaBH₄; HCl in EtOH / 7 h / 0 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: 53 percent / tetrahydrofuran; hexane / 19 h / -78 - 20 °C

With hydrogenchloride; sodium tetrahydroborate; n-butyllithium; In tetrahydrofuran; hexane;
DOI:10.1021/jo0493572