Chemical Property of Leptomycin A
Chemical Property:
- Vapor Pressure:8.56E-24mmHg at 25°C
- Boiling Point:717.7°C at 760 mmHg
- Flash Point:224.2°C
- PSA：100.90000
- Density:1.079g/cm3
- LogP:6.39460
- Storage Temp.:?20°C
- XLogP3:7.4
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:14
- Exact Mass:526.32943918
- Heavy Atom Count:38
- Complexity:1010
- Purity/Quality:
-
99%, *data from raw suppliers
Leptomycin A
*data from reagent suppliers
Safty Information:
- Pictogram(s):
F,T
- Hazard Codes:F,T
- Statements:
11-23/24/25-39/23/24/25
- Safety Statements:
16-36/37-45
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC1C=CC(=O)OC1C=CC(=CC(C)CC=CC(=CC(C)C(=O)C(C)C(C(C)CC(=CC(=O)O)C)O)C)C
- Isomeric SMILES:CC1C=CC(=O)OC1/C=C/C(=C/C(C)C/C=C/C(=C/C(C)C(=O)C(C)C(C(C)C/C(=C/C(=O)O)/C)O)/C)/C
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Description
Leptomycin A is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A inhibits Rev translocation, though less potently than leptomycin B with IC50 values of 0.8 and 0.1 nM, respectively after 7 hours. Rev export to the cytoplasm is required for HIV-1 replication. Leptomycin A was originally identified as an antifungal agent.
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Uses
Leptomycin A is an antifungal antibiotic. Leptomycin A, a methyl analogue of leptomycin B, is a minor component of the leptomycin complex produced by selected Streptomyces species. Leptomycin B is a potent inhibitor of the nuclear transport receptor CRM1. Leptomycin A is also likely to inhibit nuclear transport and may offer differences in exporter selectivity. Leptomycin A shows antimicrobial activity against Schizosaccaromyces pombe and Mucor rouxianus.
