Butanoic acid, 4-[[1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-oxo-1-(phenylmethyl) propyl]amino]ethyl]-2-phenyl-5-pyrimidinyl]amino]-4-oxo-, methyl ester

Base Information

Chemical Name:Butanoic acid, 4-[[1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-oxo-1-(phenylmethyl) propyl]amino]ethyl]-2-phenyl-5-pyrimidinyl]amino]-4-oxo-, methyl ester
CAS No.:184710-06-3
Molecular Formula:C27H25F3N4O6
Molecular Weight:558.514
Hs Code.:
Mol file:184710-06-3.mol

Butanoic acid,
4-[[1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-oxo-1-(phenylmethyl)
propyl]amino]ethyl]-2-phenyl-5-pyrimidinyl]amino]-4-oxo-, methyl ester

Synonyms:

Suppliers and Price of Butanoic acid, 4-[[1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-oxo-1-(phenylmethyl) propyl]amino]ethyl]-2-phenyl-5-pyrimidinyl]amino]-4-oxo-, methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Butanoic acid, 4-[[1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-oxo-1-(phenylmethyl) propyl]amino]ethyl]-2-phenyl-5-pyrimidinyl]amino]-4-oxo-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Butanoic acid, 4-[[1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-oxo-1-(phenylmethyl) propyl]amino]ethyl]-2-phenyl-5-pyrimidinyl]amino]-4-oxo-, methyl ester

There total 5 articles about Butanoic acid, 4-[[1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-oxo-1-(phenylmethyl) propyl]amino]ethyl]-2-phenyl-5-pyrimidinyl]amino]-4-oxo-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 184709-48-6
2-(5-amino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide

: 1490-25-1
succinic acid monomethylester chloride

: 184710-06-3
N-{1-[(1-benzyl-3,3,3-trifluoro-2-oxo-propylcarbamoyl)-methyl]-6-oxo-2-phenyl-1,6-dihydro-pyrimidin-5-yl}-succinamic acid methyl ester

Guidance literature:: With sodium carbonate; In tetrahydrofuran; at 0 ℃; for 2h;
DOI:10.1016/S0968-0896(00)00244-3

Reference yield:

: 124044-49-1
3-amino-1,1,1-trifluoro-4-phenyl-2-butanol

: 184710-06-3
N-{1-[(1-benzyl-3,3,3-trifluoro-2-oxo-propylcarbamoyl)-methyl]-6-oxo-2-phenyl-1,6-dihydro-pyrimidin-5-yl}-succinamic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / HOBT; EDC / dimethylformamide / 16 h / 20 °C

2: 65 percent / EDC; Cl₂CHCO₂H / dimethylsulfoxide; toluene / 2.5 h / 20 °C

3: 92 percent / anisole; CF₃SO₃H / CH₂Cl₂ / 1 h / 0 - 20 °C

4: 76 percent / Na₂CO₃ / tetrahydrofuran / 2 h / 0 °C

With dichloro-acetic acid; trifluorormethanesulfonic acid; sodium carbonate; benzotriazol-1-ol; methoxybenzene; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 1: condensation / 2: oxidation / 3: deacylation / 4: acylation;
DOI:10.1016/S0968-0896(00)00244-3

Reference yield:

: 148747-59-5
5-benzyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydropyrimidin-1-ylmethylcarboxylic acid

: 184710-06-3
N-{1-[(1-benzyl-3,3,3-trifluoro-2-oxo-propylcarbamoyl)-methyl]-6-oxo-2-phenyl-1,6-dihydro-pyrimidin-5-yl}-succinamic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / HOBT; EDC / dimethylformamide / 16 h / 20 °C

2: 65 percent / EDC; Cl₂CHCO₂H / dimethylsulfoxide; toluene / 2.5 h / 20 °C

3: 92 percent / anisole; CF₃SO₃H / CH₂Cl₂ / 1 h / 0 - 20 °C

4: 76 percent / Na₂CO₃ / tetrahydrofuran / 2 h / 0 °C

With dichloro-acetic acid; trifluorormethanesulfonic acid; sodium carbonate; benzotriazol-1-ol; methoxybenzene; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 1: condensation / 2: oxidation / 3: deacylation / 4: acylation;
DOI:10.1016/S0968-0896(00)00244-3