Carbamic acid, [1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-hydroxy-1-(phenylmethyl )propyl]amino]ethyl]-2-phenyl-5-pyrimidinyl]-, phenylmethyl ester

Base Information

Chemical Name:Carbamic acid, [1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-hydroxy-1-(phenylmethyl )propyl]amino]ethyl]-2-phenyl-5-pyrimidinyl]-, phenylmethyl ester
CAS No.:184711-32-8
Molecular Formula:C30H27F3N4O5
Molecular Weight:580.563
Hs Code.:
Mol file:184711-32-8.mol

Carbamic acid,
[1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-hydroxy-1-(phenylmethyl
)propyl]amino]ethyl]-2-phenyl-5-pyrimidinyl]-, phenylmethyl ester

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Chemical Property of Carbamic acid, [1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-hydroxy-1-(phenylmethyl )propyl]amino]ethyl]-2-phenyl-5-pyrimidinyl]-, phenylmethyl ester

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Technology Process of Carbamic acid, [1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-hydroxy-1-(phenylmethyl )propyl]amino]ethyl]-2-phenyl-5-pyrimidinyl]-, phenylmethyl ester

There total 1 articles about Carbamic acid, [1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-hydroxy-1-(phenylmethyl )propyl]amino]ethyl]-2-phenyl-5-pyrimidinyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 124044-49-1
3-amino-1,1,1-trifluoro-4-phenyl-2-butanol

: 148747-59-5
5-benzyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydropyrimidin-1-ylmethylcarboxylic acid

: 184711-32-8
2-(5-benzyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-hydroxypropyl)acetamide

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1016/S0968-0896(00)00244-3

Reference yield: 90.0%

: 184711-32-8
2-(5-benzyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-hydroxypropyl)acetamide

: 2-(5-amino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-N-(1-benzyl-3,3,3-trifluoro-2-hydroxy-propyl)-acetamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 2.5h;
DOI:10.1016/S0968-0896(00)00244-3

Reference yield: 65.0%

: 184711-32-8
2-(5-benzyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-hydroxypropyl)acetamide

: 184709-47-5
2-(5-benzyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide

Guidance literature:: With dichloro-acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dimethyl sulfoxide; toluene; at 20 ℃; for 2.5h;
DOI:10.1016/S0968-0896(00)00244-3