Chemical Property of Trimethaphan
Chemical Property:
- PSA：48.85000
- LogP:3.53170
- XLogP3:3.6
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:1
- Rotatable Bond Count:4
- Exact Mass:365.16875960
- Heavy Atom Count:26
- Complexity:514
- Purity/Quality:
-
98% *data from raw suppliers
TRIMETHAPHAN 95.00% *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1CC2C3C(C[S+]2C1)N(C(=O)N3CC4=CC=CC=C4)CC5=CC=CC=C5
- Recent ClinicalTrials:Reduction in Splanchnic Capacitance Contributes to Sympathetically Dependent Hypertension in Autonomic
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Clinical Use
Trimethaphan camsylate (Arfonad) is an extremely
short-acting agent whose major therapeutic use is in the
production of controlled hypotension in certain surgical procedures and in the emergency treatment of hypertensive
crisis. Continuous infusion may be employed to
maintain its antihypertensive effect, especially in patients
with an acute dissecting aortic aneurysm. Much of
the decrease in blood pressure following trimethaphan
administration is thought to be due to its direct vasodilating
properties.
Trimethaphan can produce prolonged neuromuscular
blockade in some patients, and therefore, it
should be used with caution as a hypotensive agent
during surgery. It also has been reported to potentiate
the neuromuscular blocking action of tubocurarine,
and because of its histamine-releasing properties,
trimethaphan should be used with caution in patients
with allergies.
