Technology Process of 3'-deoxycytidine 5'-triphosphate
There total 9 articles about 3'-deoxycytidine 5'-triphosphate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap;
In
water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 85 percent / phosphoryl chloride, triethylphosphate / 4 h / 0 °C
2: 1.) N,N'carbonyldiimidazole, 2.) tri-n-butylammonium pyrophosphate / 1.) DMF, RT, 3.5 h, 2.) DMF, RT, 24 h
With
triethyl phosphate; tri(n-butyl)ammonium pyrophosphate; 1,1'-carbonyldiimidazole; trichlorophosphate;
DOI:10.1248/cpb.43.2005
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 78 percent / TMS-triflate / acetonitrile / 24 h / Ambient temperature
2: 50 percent / 0.05 N methanolic sodium methoxide / 3 h / 50 °C
3: 85 percent / phosphoryl chloride, triethylphosphate / 4 h / 0 °C
4: 1.) N,N'carbonyldiimidazole, 2.) tri-n-butylammonium pyrophosphate / 1.) DMF, RT, 3.5 h, 2.) DMF, RT, 24 h
With
triethyl phosphate; trimethylsilyl trifluoromethanesulfonate; sodium methylate; tri(n-butyl)ammonium pyrophosphate; 1,1'-carbonyldiimidazole; trichlorophosphate;
In
acetonitrile;
DOI:10.1248/cpb.43.2005