2-(3-Aminophenoxy)-1-morpholinoethanone

Base Information

• Chemical Name: 2-(3-Aminophenoxy)-1-morpholinoethanone
• CAS No.: 184944-87-4
• Molecular Formula: C12H16N2O3
• Molecular Weight: 236.271
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID00351903
• Wikidata: Q82128729
• ChEMBL ID: CHEMBL236352
• Mol file: 184944-87-4.mol

Synonyms:184944-87-4;2-(3-aminophenoxy)-1-morpholinoethanone;[3-(2-morpholin-4-yl-2-oxoethoxy)phenyl]amine;2-(3-aminophenoxy)-1-morpholin-4-ylethanone;3-[2-(4-MORPHOLINYL)-2-OXOETHOXY]ANILINE;CHEMBL236352;CHEMBRDG-BB 7949765;2-(3-aminophenoxy)-1-(morpholin-4-yl)ethan-1-one;2-(3-aminophenoxy)-1-(morpholin-4-yl)ethanone;SCHEMBL2229109;DTXSID00351903;SQKMJEPQICGMPL-UHFFFAOYSA-N;HMS1599K15;BDBM50228170;MFCD03768367;STK734860;AKOS000209637;LS-03487;MLS-0067069.P001;2-(3-Aminophenoxy)-1-morpholinoethan-1-one;CS-0313264;FT-0683230;2-(3-Amino-phenoxy)-1-morpholin-4-yl-ethanone

Chemical Property of 2-(3-Aminophenoxy)-1-morpholinoethanone

Chemical Property:

• Vapor Pressure: 1.44E-09mmHg at 25°C
• Boiling Point: 485.2oC at 760 mmHg
• Flash Point: 247.3oC
• PSA: 64.79000
• Density: 1.24g/cm3
• LogP: 1.02550
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 236.11609238
• Heavy Atom Count: 17
• Complexity: 254

Purity/Quality:

98%min ^*data from raw suppliers

[3-(2-Morpholin-4-yl-2-oxoethoxy)phenyl]amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C(=O)COC2=CC=CC(=C2)N

Technology Process of 2-(3-Aminophenoxy)-1-morpholinoethanone

There total 9 articles about 2-(3-Aminophenoxy)-1-morpholinoethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.67%

4-[(3-nitro-phenoxy)-acetyl]-morpholine (50508-38-8) → N-(2-(3-aminophenoxy)acetyl)morpholine (184944-87-4)

Guidance literature:

With hydrogen; palladium carbon (20 wt%); In ethyl acetate; at 20 ℃; for 2h;

Reference yield: 86.0%

→ N-(2-(3-aminophenoxy)acetyl)morpholine (184944-87-4)

Guidance literature:

Reference yield:

2-(3-nitrophenoxy)acetic acid (1878-88-2) → N-(2-(3-aminophenoxy)acetyl)morpholine (184944-87-4)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 3 h / Ambient temperature

2: NH₃ / methanol; tetrahydrofuran / 6 h / Ambient temperature

3: H₂ / 10percent Pd/C / ethyl acetate / 1 h

With ammonia; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate;

DOI:10.1021/jm9601664

upstream raw materials:

4-[(3-nitro-phenoxy)-acetyl]-morpholine

meta-nitrophenol

tert-butyl 2-(3-nitrophenoxy)acetate

2-(3-nitrophenoxy)acetic acid