L-Phenylalanine, N-[4-(10,10-dimethyl-8-oxo-3-thioxo-9-oxa-2,4,7-triazaundec-1-yl)benz oyl]-, methyl ester

Base Information

Chemical Name:L-Phenylalanine, N-[4-(10,10-dimethyl-8-oxo-3-thioxo-9-oxa-2,4,7-triazaundec-1-yl)benz oyl]-, methyl ester
CAS No.:184954-64-1
Molecular Formula:C26H34N4O5S
Molecular Weight:514.646
Hs Code.:
Mol file:184954-64-1.mol

Synonyms:

Suppliers and Price of L-Phenylalanine, N-[4-(10,10-dimethyl-8-oxo-3-thioxo-9-oxa-2,4,7-triazaundec-1-yl)benz oyl]-, methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of L-Phenylalanine, N-[4-(10,10-dimethyl-8-oxo-3-thioxo-9-oxa-2,4,7-triazaundec-1-yl)benz oyl]-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of L-Phenylalanine, N-[4-(10,10-dimethyl-8-oxo-3-thioxo-9-oxa-2,4,7-triazaundec-1-yl)benz oyl]-, methyl ester

There total 4 articles about L-Phenylalanine, N-[4-(10,10-dimethyl-8-oxo-3-thioxo-9-oxa-2,4,7-triazaundec-1-yl)benz oyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 137743-46-5
2-tert-butyloxycarbonylaminoethyl isothiocyanate

: 184954-66-3
(S)-2-(4-Aminomethyl-benzoylamino)-3-phenyl-propionic acid methyl ester

: 184954-64-1
(S)-2-{4-[3-(2-tert-Butoxycarbonylamino-ethyl)-thioureidomethyl]-benzoylamino}-3-phenyl-propionic acid methyl ester

Guidance literature:: In dichloromethane; for 96h; Ambient temperature;
DOI:10.1021/jo9614102

Reference yield:

: 56-91-7
p-aminomethylbenzoic acid

: 184954-64-1
(S)-2-{4-[3-(2-tert-Butoxycarbonylamino-ethyl)-thioureidomethyl]-benzoylamino}-3-phenyl-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / NaOH / H₂O; 2-methyl-propan-2-ol / 18 h

2: 1.) K₂CO₃, 2.) DCC / 1.) H₂O, 2.) DCM, DMF, 18 h

3: 93 percent / TFA / H₂O / 1 h

4: 79 percent / CH₂Cl₂ / 96 h / Ambient temperature

With sodium hydroxide; potassium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/jo9614102

Reference yield:

: 33233-67-9
4-(tert-Butoxycarbonylaminomethyl)benzoic acid

: 184954-64-1
(S)-2-{4-[3-(2-tert-Butoxycarbonylamino-ethyl)-thioureidomethyl]-benzoylamino}-3-phenyl-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) K₂CO₃, 2.) DCC / 1.) H₂O, 2.) DCM, DMF, 18 h

2: 93 percent / TFA / H₂O / 1 h

3: 79 percent / CH₂Cl₂ / 96 h / Ambient temperature

With potassium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; water;
DOI:10.1021/jo9614102