8-epi-15-E2c-IsoP

Base Information

Chemical Name:8-epi-15-E2c-IsoP
CAS No.:39265-67-3
Molecular Formula:C20H32O5
Molecular Weight:352.4651
Hs Code.:
Metabolomics Workbench ID:2934
Mol file:39265-67-3.mol

Synonyms:8,12-epi-PGE2;8,12-epi-prostaglandin E2;8,12-epi-prostaglandin E2, (5Z,8beta,11alpha,12alpha,13E,15R)-isomer

Suppliers and Price of 8-epi-15-E2c-IsoP

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 8-epi-15-E2c-IsoP

Chemical Property:

Vapor Pressure:1.89E-13mmHg at 25°C
Boiling Point:530.1°Cat760mmHg
Flash Point:288.4°C
PSA：94.83000
Density:1.148g/cm³
LogP:3.25110
XLogP3:2.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:12
Exact Mass:352.22497412
Heavy Atom Count:25
Complexity:469

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCC(C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O)O
Isomeric SMILES:CCCCC[C@@H](/C=C/[C@@H]1[C@@H](CC(=O)[C@H]1C/C=C\CCCC(=O)O)O)O

Technology Process of 8-epi-15-E2c-IsoP

There total 25 articles about 8-epi-15-E2c-IsoP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 303015-41-0
(5Z,8R,9R,11S,12S,13E,15R)-11,15-bis-(tert-butyldimethylsilyloxy)-9-oxoprosta-5,13-dienoic acid

: 363-24-6,13164-28-8,22230-04-2,27415-25-4,31660-13-6,31660-17-0,36150-00-2,37495-69-5,37785-90-3,38310-90-6,38873-82-4,39265-67-3,39648-42-5,54324-09-3,54324-10-6,57759-80-5,57759-81-6,63179-97-5,65026-02-0,65085-69-0,70051-84-2,85548-91-0
ent-prostaglandin E2

: ent-15-E_2t-isoprostane

Guidance literature:: (5Z,8R,9R,11S,12S,13E,15R)-11,15-bis-(tert-butyldimethylsilyloxy)-9-oxoprosta-5,13-dienoic acid; With pyridine; hydrogen fluoride; In tetrahydrofuran; water; acetonitrile; at 20 ℃; for 6h;

With potassium acetate; In methanol; at 20 ℃; for 96h;
DOI:10.1016/S0040-4020(00)00531-7

Reference yield:

: 214748-78-4
(Z)-7-[(1R,2S,3S,5R)-5-Acetoxy-3-hydroxy-2-((E)-(R)-3-hydroxy-oct-1-enyl)-cyclopentyl]-hept-5-enoic acid ethyl ester

: 363-24-6,13164-28-8,22230-04-2,27415-25-4,31660-13-6,31660-17-0,36150-00-2,37495-69-5,37785-90-3,38310-90-6,38873-82-4,39265-67-3,39648-42-5,54324-09-3,54324-10-6,57759-80-5,57759-81-6,63179-97-5,65026-02-0,65085-69-0,70051-84-2,85548-91-0
ent-prostaglandin E2

Guidance literature:: Multi-step reaction with 4 steps

1.1: 82 percent / imidazole; DMAP / CH₂Cl₂ / 24 h / 20 °C

2.1: 92 percent / LiOH*H₂O / tetrahydrofuran; H₂O; methanol / 24 h / 20 °C

3.1: 95 percent / Dess-Martin periodinate / CH₂Cl₂ / 20 h / 20 °C

4.1: HF; pyridine / H₂O; tetrahydrofuran; acetonitrile / 6 h / 20 °C

4.2: KOAc / methanol / 96 h / 20 °C

With pyridine; 1H-imidazole; dmap; lithium hydroxide; hydrogen fluoride; Dess-Martin periodane; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile; 1.1: Substitution / 2.1: Hydrolysis / 3.1: Oxidation / 4.1: Hydrolysis / 4.2: Isomerization;
DOI:10.1016/S0040-4020(00)00531-7

Reference yield:

: 303015-43-2
(5Z,8R,9R,11S,12S,13E,15R)-11,15-bis-(tert-butyldimethylsilyloxy)-9-hydroxyprosta-5,13-dienoic acid

: 363-24-6,13164-28-8,22230-04-2,27415-25-4,31660-13-6,31660-17-0,36150-00-2,37495-69-5,37785-90-3,38310-90-6,38873-82-4,39265-67-3,39648-42-5,54324-09-3,54324-10-6,57759-80-5,57759-81-6,63179-97-5,65026-02-0,65085-69-0,70051-84-2,85548-91-0
ent-prostaglandin E2

Guidance literature:: Multi-step reaction with 2 steps

1.1: 95 percent / Dess-Martin periodinate / CH₂Cl₂ / 20 h / 20 °C

2.1: HF; pyridine / H₂O; tetrahydrofuran; acetonitrile / 6 h / 20 °C

2.2: KOAc / methanol / 96 h / 20 °C

With pyridine; hydrogen fluoride; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; water; acetonitrile; 1.1: Oxidation / 2.1: Hydrolysis / 2.2: Isomerization;
DOI:10.1016/S0040-4020(00)00531-7