1-(4-chlorobenzyl)-(1H-1，2，4-triazol-yl)-pinacolone

Base Information

Chemical Name:1-(4-chlorobenzyl)-(1H-1，2，4-triazol-yl)-pinacolone
CAS No.:107021-84-1
Molecular Formula:C₁₅H₁₈ClN₃O
Molecular Weight:291.78
Hs Code.:
Mol file:107021-84-1.mol

Synonyms:1H-1,2,4-Triazole,1-[2-[(4-chlorophenyl)methyl]-3,3-dimethyl-1-oxobutyl]- (9CI)

Suppliers and Price of 1-(4-chlorobenzyl)-(1H-1，2，4-triazol-yl)-pinacolone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 1-(4-chlorobenzyl)-(1H-1，2，4-triazol-yl)-pinacolone

Chemical Property:

Vapor Pressure:1.08E-07mmHg at 25°C
Boiling Point:432.8°Cat760mmHg
Flash Point:215.6°C
PSA：47.78000
Density:1.18g/cm³
LogP:3.47670

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-(4-chlorobenzyl)-(1H-1，2，4-triazol-yl)-pinacolone

There total 5 articles about 1-(4-chlorobenzyl)-(1H-1，2，4-triazol-yl)-pinacolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69341-75-9
N,N-dimethylfluoroamide-di-tert-butyl acetate

: 107021-84-1
2-(4-Chloro-benzyl)-3,3-dimethyl-1-[1,2,4]triazol-1-yl-butan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.a) diisopropylamine, n-BuLi; 2.a) HMPA / 1.a) THF, hexane, 0 deg C, 10 min; 1.b) THF, hexane, 0 deg C, 30 min; 2.a) THF, hexane, -50 deg C, 1 h; 2.b) r.t., overnight

2: 95.8 g / trifluoroacetic acid / CH₂Cl₂ / 5 h / Ambient temperature

3: 77.8 g / thionyl chloride / benzene / 1 h / Heating

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; thionyl chloride; diisopropylamine; trifluoroacetic acid; In dichloromethane; benzene;

Reference yield:

: 104-83-6
1-Chloro-4-(chloromethyl)benzene

: 107021-84-1
2-(4-Chloro-benzyl)-3,3-dimethyl-1-[1,2,4]triazol-1-yl-butan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.a) diisopropylamine, n-BuLi; 2.a) HMPA / 1.a) THF, hexane, 0 deg C, 10 min; 1.b) THF, hexane, 0 deg C, 30 min; 2.a) THF, hexane, -50 deg C, 1 h; 2.b) r.t., overnight

2: 95.8 g / trifluoroacetic acid / CH₂Cl₂ / 5 h / Ambient temperature

3: 77.8 g / thionyl chloride / benzene / 1 h / Heating

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; thionyl chloride; diisopropylamine; trifluoroacetic acid; In dichloromethane; benzene;

Reference yield:

: 110577-60-1
tert-butyl 2-(4-chlorobenzyl)-3,3-dimethylbutanoate

: 107021-84-1
2-(4-Chloro-benzyl)-3,3-dimethyl-1-[1,2,4]triazol-1-yl-butan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: 95.8 g / trifluoroacetic acid / CH₂Cl₂ / 5 h / Ambient temperature

2: 77.8 g / thionyl chloride / benzene / 1 h / Heating

With thionyl chloride; trifluoroacetic acid; In dichloromethane; benzene;