(4-Hydroxy-5-isopropyl-2-methyl-phenyl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:(4-Hydroxy-5-isopropyl-2-methyl-phenyl)-carbamic acid tert-butyl ester
CAS No.:185063-82-5
Molecular Formula:C15H23NO3
Molecular Weight:265.34800
Hs Code.:
DSSTox Substance ID:DTXSID10444471
Wikidata:Q82262611
Mol file:185063-82-5.mol

Synonyms:(4-Hydroxy-5-isopropyl-2-methyl-phenyl)-carbamic acid tert-butyl ester;185063-82-5;tert-butyl N-(4-hydroxy-2-methyl-5-propan-2-ylphenyl)carbamate;DTXSID10444471;MXPZGXOTSOJFQM-UHFFFAOYSA-N;EN300-12442127;tert-butyl N-[4-hydroxy-2-methyl-5-(propan-2-yl)phenyl]carbamate

Suppliers and Price of (4-Hydroxy-5-isopropyl-2-methyl-phenyl)-carbamic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynChem
(4-Hydroxy-5-isopropyl-2-methyl-phenyl)-carbamic acid tert-butyl ester 95+%
1 g
$ 180.00

SynChem
(4-Hydroxy-5-isopropyl-2-methyl-phenyl)-carbamic acid tert-butyl ester 95+%
5 g
$ 625.00

American Custom Chemicals Corporation
(4-HYDROXY-5-ISOPROPYL-2-METHYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER 95.00%
5MG
$ 502.83

Total 1 raw suppliers

Chemical Property of (4-Hydroxy-5-isopropyl-2-methyl-phenyl)-carbamic acid tert-butyl ester

Chemical Property:

PSA：58.56000
LogP:4.24400
XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:265.16779360
Heavy Atom Count:19
Complexity:309

Purity/Quality:

98%Min ^*data from raw suppliers

(4-Hydroxy-5-isopropyl-2-methyl-phenyl)-carbamic acid tert-butyl ester 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=C(C=C1NC(=O)OC(C)(C)C)C(C)C)O

Technology Process of (4-Hydroxy-5-isopropyl-2-methyl-phenyl)-carbamic acid tert-butyl ester

There total 1 articles about (4-Hydroxy-5-isopropyl-2-methyl-phenyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1128-28-5
4-aminothymol

: 185063-82-5
(4-Hydroxy-5-isopropyl-2-methyl-phenyl)-carbamic acid tert-butyl ester

Guidance literature:: In tetrahydrofuran; for 4h; Heating;
DOI:10.1021/jm960485v

Reference yield:

: 185063-82-5
(4-Hydroxy-5-isopropyl-2-methyl-phenyl)-carbamic acid tert-butyl ester

: 185064-25-9
2-(1-Benzyl-2-ethyl-6-isopropyl-5-methoxy-1H-indol-3-yl)-2-oxo-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaH / 1.) DMF, 1 h, 2.) DMF, 17 h

2: 1.) s-BuLi / 1.) cyclohexane, THF, -40 deg C, 0.25 h, 2.) cyclohexane, THF, from -40 deg C to RT, 2 h

3: 62 percent / CF₃COOH / CH₂Cl₂ / 72 h

4: 1.) NaH / 1.) DMF, 1 h ,2.) DMF, 3.5 h

5: CH₂Cl₂ / 1 h

6: NH₃ / CH₂Cl₂ / 0.25 h

With ammonia; sec.-butyllithium; sodium hydride; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm960485v

Reference yield:

: 185063-82-5
(4-Hydroxy-5-isopropyl-2-methyl-phenyl)-carbamic acid tert-butyl ester

: 1027852-36-3
(1-Benzyl-2-ethyl-6-isopropyl-5-methoxy-1H-indol-3-yl)-oxo-acetyl chloride

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) DMF, 1 h, 2.) DMF, 17 h

2: 1.) s-BuLi / 1.) cyclohexane, THF, -40 deg C, 0.25 h, 2.) cyclohexane, THF, from -40 deg C to RT, 2 h

3: 62 percent / CF₃COOH / CH₂Cl₂ / 72 h

4: 1.) NaH / 1.) DMF, 1 h ,2.) DMF, 3.5 h

5: CH₂Cl₂ / 1 h

With sec.-butyllithium; sodium hydride; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm960485v