Piperazine, 4-[[3,5-bis(trifluoromethyl)phenyl]acetyl]-2-phenyl-1-[[[1-(phenylmethyl)-4 -piperidinyl]amino]acetyl]-

Base Information

Chemical Name:Piperazine, 4-[[3,5-bis(trifluoromethyl)phenyl]acetyl]-2-phenyl-1-[[[1-(phenylmethyl)-4 -piperidinyl]amino]acetyl]-
CAS No.:185108-03-6
Molecular Formula:C34H36F6N4O2
Molecular Weight:646.676
Hs Code.:
Mol file:185108-03-6.mol

Synonyms:

Suppliers and Price of Piperazine, 4-[[3,5-bis(trifluoromethyl)phenyl]acetyl]-2-phenyl-1-[[[1-(phenylmethyl)-4 -piperidinyl]amino]acetyl]-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Piperazine, 4-[[3,5-bis(trifluoromethyl)phenyl]acetyl]-2-phenyl-1-[[[1-(phenylmethyl)-4 -piperidinyl]amino]acetyl]-

Chemical Property:

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Technology Process of Piperazine, 4-[[3,5-bis(trifluoromethyl)phenyl]acetyl]-2-phenyl-1-[[[1-(phenylmethyl)-4 -piperidinyl]amino]acetyl]-

There total 9 articles about Piperazine, 4-[[3,5-bis(trifluoromethyl)phenyl]acetyl]-2-phenyl-1-[[[1-(phenylmethyl)-4 -piperidinyl]amino]acetyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 185108-03-6
(+,)-4-[[3,5-bis(trifluoromethyl)phenyl]acetyl]-2-phenyl-1-[[[1-(phenylmethyl)-4-piperidinyl]amino]acetyl]piperazine

Guidance literature:

Reference yield:

: 5271-26-1
m-phenylpiperazine

: 185108-03-6
(+,)-4-[[3,5-bis(trifluoromethyl)phenyl]acetyl]-2-phenyl-1-[[[1-(phenylmethyl)-4-piperidinyl]amino]acetyl]piperazine

Guidance literature:: Multi-step reaction with 5 steps

1: methanol / -78 °C

2: (i-Pr)2NEt / CH₂Cl₂

3: HCl / dioxane

4: HOBt; Et₃N; DEC

With hydrogenchloride; diethylcarbamazine; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1016/S0960-894X(02)00645-5

Reference yield:

: phenylmagnesium bromide

: 185108-03-6
(+,)-4-[[3,5-bis(trifluoromethyl)phenyl]acetyl]-2-phenyl-1-[[[1-(phenylmethyl)-4-piperidinyl]amino]acetyl]piperazine

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / (Ph₂PCH₂)2NiCl₂ / tetrahydrofuran

2: 75 percent / H₂; Pd(OAc)2; AcOH / 4 h / 2585.74 Torr

3: methanol / -78 °C

4: (i-Pr)2NEt / CH₂Cl₂

5: HCl / dioxane

6: HOBt; Et₃N; DEC

With hydrogenchloride; palladium diacetate; diethylcarbamazine; 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; hydrogen; benzotriazol-1-ol; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
DOI:10.1016/S0960-894X(02)00645-5