[4-[1-(4,4'-Dihydroxybenzhydrylidene)propyl]phenoxy]acetic acid

Base Information

Chemical Name:[4-[1-(4,4'-Dihydroxybenzhydrylidene)propyl]phenoxy]acetic acid
CAS No.:185223-86-3
Molecular Formula:C24H22O5
Molecular Weight:390.436
Hs Code.:
DSSTox Substance ID:DTXSID20442605
Nikkaji Number:J796.940F
ChEMBL ID:CHEMBL145356
Mol file:185223-86-3.mol

Synonyms:CHEMBL145356;185223-86-3;[4-[1-(4,4'-Dihydroxybenzhydrylidene)propyl]phenoxy]acetic acid;SCHEMBL3812915;DTXSID20442605;VGBGCLVQISVXAH-UHFFFAOYSA-N;2-[4-[1,1-bis(4-hydroxyphenyl)but-1-en-2-yl]phenoxy]acetic Acid;BDBM50470953;({4-[1-ethyl-2,2-bis(4-hydroxyphenyl)ethenyl]phenyl}oxy)acetic acid

Suppliers and Price of [4-[1-(4,4'-Dihydroxybenzhydrylidene)propyl]phenoxy]acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of [4-[1-(4,4'-Dihydroxybenzhydrylidene)propyl]phenoxy]acetic acid

Chemical Property:

XLogP3:6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:390.14672380
Heavy Atom Count:29
Complexity:524

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC(=C(C1=CC=C(C=C1)O)C2=CC=C(C=C2)O)C3=CC=C(C=C3)OCC(=O)O

Technology Process of [4-[1-(4,4'-Dihydroxybenzhydrylidene)propyl]phenoxy]acetic acid

There total 6 articles about [4-[1-(4,4'-Dihydroxybenzhydrylidene)propyl]phenoxy]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 185223-86-3
({4-[1-ethyl-2,2-bis(4-hydroxyphenyl)ethenyl]phenyl}oxy)acetic acid

Guidance literature:

Reference yield:

: 1026583-78-7
(4-{1-[Bis-(4-benzyloxy-phenyl)-methylene]-propyl}-phenoxy)-acetic acid

: 185223-86-3
({4-[1-ethyl-2,2-bis(4-hydroxyphenyl)ethenyl]phenyl}oxy)acetic acid

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; In tetrahydrofuran; for 11.5h; under 2275.5 Torr; Yield given;
DOI:10.1021/jm960517e

Reference yield:

: 611-99-4
4,4'-Dihydroxybenzophenone

: 185223-86-3
({4-[1-ethyl-2,2-bis(4-hydroxyphenyl)ethenyl]phenyl}oxy)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / NaH / dimethylformamide / 3.5 h / 50 °C

2: 42 percent / Zn, TiCl₄ / tetrahydrofuran / 4 h / Heating

3: K₂CO₃ / acetone / 6 h / Heating

4: 5percent aq. NaOH / dioxane / 0.5 h

5: H₂, AcOH / 10percent Pd/C / tetrahydrofuran / 11.5 h / 2275.5 Torr

With sodium hydroxide; hydrogen; titanium tetrachloride; sodium hydride; potassium carbonate; acetic acid; zinc; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm960517e