Chemical Property of Gastrodin
Chemical Property:
- Appearance/Colour:White crystal.
- Vapor Pressure:1.6E-13mmHg at 25°C
- Melting Point:154-157oC
- Refractive Index:1.638
- Boiling Point:563.2 °C at 760 mmHg
- PKA:9.10(at 25℃)
- Flash Point:294.4 °C
- PSA：119.61000
- Density:1.504 g/cm3
- LogP:-1.64240
- Storage Temp.:2-8°C
- Solubility.:DMSO (Slightly, Sonicated), Methanol (Slightly), Water (Slightly, Sonicated)
- XLogP3:-0.8
- Hydrogen Bond Donor Count:5
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:4
- Exact Mass:286.10525291
- Heavy Atom Count:20
- Complexity:292
- Purity/Quality:
-
99% *data from raw suppliers
Gastrodin *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1=CC(=CC=C1CO)OC2C(C(C(C(O2)CO)O)O)O
- Isomeric SMILES:C1=CC(=CC=C1CO)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O
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Description
Gastrodin is extracted from the dry root of the orchid plant, Gastrodia elata. The
source of raw materials is Yunnan Province. Traditional Chinese medicine Gastrodia
elata (Gastrodia elata Bl.) is also known as Chi Jian, Ding Feng Cao, Shui Yang Yu,
and so on, belonging to special symbiosis perennial herb of Orchidaceae and
Armillaria mellea. The medicinal part is its tubers. It has sweet flavor and liver
channel tropism and is neutral in nature. Traditional Chinese medicine believes that
its main functions are to expel wind and relieve convulsion, calm the liver and suppress liver-yang, and expel wind evil and channel. There are 23 chemical ingredients extracted from Gastrodia elata, including gastrodin, gastrodia glycosides,
vanilla alcohol, vanilla aldehyde, beta steroid valley alcohol, p-hydroxybenzoic
acid, carrot glycosides, and so on, among which the highest content of single active
ingredient is Gastrodia glycosides, namely, gastrodin
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Physical properties
Appearance: white prismatic crystal, odorless, and bitter; little hygroscopicity.
Solubility: soluble in water, methanol, ethanol, acetone, and acetonyl acetate, insoluble in chloroform, and poorly soluble in ethyl ether. Melting point: ?153 to 156?°C.
Specific optical rotation: ?68 to ?72° .
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Uses
Gastrodin up regulates heme oxygenase-1 expression through activation of p38 MAPK/Nrf2 signaling pathway thus protecting the SH-SY5Y cells from MPP+-induced oxidative cell death.
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Indications
Gastrodin is included in the International Pharmacopoeia (5th ed.).
The dosage forms include injections, tablets, and capsules. They are widely used
for the treatment of vertigo (Meniere’s disease, medicinal dizziness, traumatic vertigo, sudden deafness, vestibular neuronitis, vertebrobasilar insufficiency, etc.),
headache (vascular headache, migraine, etc.), neuralgia (trigeminal neuralgia, sciatica, etc.), neurasthenia syndrome, and brain traumatic syndrome .
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Clinical Use
Gastrodin has sedative and hypnotic, analgesia, and immune enhancement function
and is used for the treatment of tension headache to relieve pain and intense sentiment and thus further relieve the related symptoms . Clinical usage of gastrodin
acupoint injection to treat insomnia also achieves certain effect . Moreover, gastrodin agents have been used for the treatment of cardiovascular diseases and microcirculation system, such as hypertension and coronary heart disease without
obvious side effects .It is also reported that gastrodin can treat epilepsy, vascular dementia, deafness,
tinnitus, herpes zoster, osteoarthritis, cognitive impairment, and so on but still needs
further investigation.
