Butanoic acid, 4-[[3-(2-amino-2-oxoethyl)-2-ethyl-6-(1-methylethyl)-1-(phenylmethyl)-1H -indol-5-yl]thio]-, ethyl ester

Base Information

Chemical Name:Butanoic acid, 4-[[3-(2-amino-2-oxoethyl)-2-ethyl-6-(1-methylethyl)-1-(phenylmethyl)-1H -indol-5-yl]thio]-, ethyl ester
CAS No.:185501-49-9
Molecular Formula:C28H36N2O3S
Molecular Weight:480.671
Hs Code.:
Mol file:185501-49-9.mol

Synonyms:

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Chemical Property of Butanoic acid, 4-[[3-(2-amino-2-oxoethyl)-2-ethyl-6-(1-methylethyl)-1-(phenylmethyl)-1H -indol-5-yl]thio]-, ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of Butanoic acid, 4-[[3-(2-amino-2-oxoethyl)-2-ethyl-6-(1-methylethyl)-1-(phenylmethyl)-1H -indol-5-yl]thio]-, ethyl ester

There total 10 articles about Butanoic acid, 4-[[3-(2-amino-2-oxoethyl)-2-ethyl-6-(1-methylethyl)-1-(phenylmethyl)-1H -indol-5-yl]thio]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-[1-Benzyl-3-(carbamoyl-hydroxy-methyl)-2-ethyl-6-isopropyl-1H-indol-5-ylsulfanyl]-butyric acid ethyl ester

: 185501-49-9
4-(1-Benzyl-3-carbamoylmethyl-2-ethyl-6-isopropyl-1H-indol-5-ylsulfanyl)-butyric acid ethyl ester

Guidance literature:: With triethylsilane; trifluoroacetic acid; In dichloromethane; for 2h;
DOI:10.1021/jm960486n

Reference yield:

: 2969-81-5
Ethyl 4-bromobutyrate

: 185501-49-9
4-(1-Benzyl-3-carbamoylmethyl-2-ethyl-6-isopropyl-1H-indol-5-ylsulfanyl)-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 81 percent / NaH / dimethylformamide / 18 h

2: CH₂Cl₂ / 3 h

3: HN₃ gas / CH₂Cl₂ / 16 h

4: NaBH₄ / ethanol / 20 h

5: triethylsilane, trifluoroacetic acid / CH₂Cl₂ / 2 h

With triethylsilane; sodium tetrahydroborate; hydrogen azide; sodium hydride; trifluoroacetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm960486n

Reference yield:

: 185501-38-6
1-Benzyl-2-ethyl-6-isopropyl-1H-indol-5-ol

: 185501-49-9
4-(1-Benzyl-3-carbamoylmethyl-2-ethyl-6-isopropyl-1H-indol-5-ylsulfanyl)-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 73 percent / NaH / dimethylformamide / 22 h

2: 50 percent / diphenyl ether / 28 h / Heating

3: 5N aq. NaOH / ethanol / 5 h / Heating

4: 81 percent / NaH / dimethylformamide / 18 h

5: CH₂Cl₂ / 3 h

6: HN₃ gas / CH₂Cl₂ / 16 h

7: NaBH₄ / ethanol / 20 h

8: triethylsilane, trifluoroacetic acid / CH₂Cl₂ / 2 h

With triethylsilane; sodium hydroxide; sodium tetrahydroborate; hydrogen azide; sodium hydride; trifluoroacetic acid; In diphenylether; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm960486n