L-Tyrosine, O-(phenylmethyl)-, 2,2,6,6-tetramethyl-1-oxy-4-piperidinyl ester

Base Information

• Chemical Name: L-Tyrosine, O-(phenylmethyl)-, 2,2,6,6-tetramethyl-1-oxy-4-piperidinyl ester
• CAS No.: 185519-81-7
• Molecular Formula: C25H33N2O4
• Molecular Weight: 425.548
• Mol file: 185519-81-7.mol

Synonyms:

Chemical Property of L-Tyrosine, O-(phenylmethyl)-, 2,2,6,6-tetramethyl-1-oxy-4-piperidinyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-Tyrosine, O-(phenylmethyl)-, 2,2,6,6-tetramethyl-1-oxy-4-piperidinyl ester

There total 1 articles about L-Tyrosine, O-(phenylmethyl)-, 2,2,6,6-tetramethyl-1-oxy-4-piperidinyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.2%

TEMPOL (45985-24-8,2226-96-2) + O-benzyltyrosine methyl ester (57177-83-0) → C25H33N2O4 (185519-81-7)

Guidance literature:

With sodium methylate; In methanol; toluene; for 3h; Heating;

DOI:10.1016/0968-0896(96)00150-2

Reference yield:

C25H33N2O4 (185519-81-7) → (S)-tyrosine (1-hydroxy-2,2,6,6-tetramethylpiperidinyl) ester (185519-82-8)

Guidance literature:

With hydrogen; silica gel; palladium; In ethanol; for 4h; under 760 Torr; Ambient temperature;

DOI:10.1016/0968-0896(96)00150-2

Reference yield:

C25H33N2O4 (185519-81-7) → (S)-tyrosine, (1-oxyl-2,2,6,6-tetramethylpiperidinyl)ester

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 2percent Pd/SiO₂ / ethanol / 4 h / 760 Torr / Ambient temperature

2: PbO₂, air / diethyl ether / 15 h

With air; hydrogen; lead dioxide; silica gel; palladium; In diethyl ether; ethanol;

DOI:10.1016/0968-0896(96)00150-2

upstream raw materials:

TEMPOL

O-benzyltyrosine methyl ester

Downstream raw materials:

(S)-tyrosine (1-hydroxy-2,2,6,6-tetramethylpiperidinyl) ester