1H-1,2,4-Triazole, 1-[[(1R,2R,3S,6R)-2-methoxy-3-methyl-6-(1-methylethenyl)-3-[2-(triphen ylmethoxy)ethyl]cyclohexyl]methyl]-

Base Information

Chemical Name:1H-1,2,4-Triazole, 1-[[(1R,2R,3S,6R)-2-methoxy-3-methyl-6-(1-methylethenyl)-3-[2-(triphen ylmethoxy)ethyl]cyclohexyl]methyl]-
CAS No.:185538-87-8
Molecular Formula:C₃₅H₄₁N₃O₂
Molecular Weight:535.729
Hs Code.:
Mol file:185538-87-8.mol

Synonyms:

Suppliers and Price of 1H-1,2,4-Triazole, 1-[[(1R,2R,3S,6R)-2-methoxy-3-methyl-6-(1-methylethenyl)-3-[2-(triphen ylmethoxy)ethyl]cyclohexyl]methyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1H-1,2,4-Triazole, 1-[[(1R,2R,3S,6R)-2-methoxy-3-methyl-6-(1-methylethenyl)-3-[2-(triphen ylmethoxy)ethyl]cyclohexyl]methyl]-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1H-1,2,4-Triazole, 1-[[(1R,2R,3S,6R)-2-methoxy-3-methyl-6-(1-methylethenyl)-3-[2-(triphen ylmethoxy)ethyl]cyclohexyl]methyl]-

There total 15 articles about 1H-1,2,4-Triazole, 1-[[(1R,2R,3S,6R)-2-methoxy-3-methyl-6-(1-methylethenyl)-3-[2-(triphen ylmethoxy)ethyl]cyclohexyl]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 99-48-9,1197-06-4,1197-07-5,2102-58-1,2102-59-2,5157-78-8,5503-11-7,7632-16-8,18383-51-2,22567-18-6,20307-86-2
(4R,6R)-carveol

: 185538-87-8
1-[(1R,2R,3S,6R)-6-Isopropenyl-2-methoxy-3-methyl-3-(2-trityloxy-ethyl)-cyclohexylmethyl]-1H-[1,2,4]triazole

Guidance literature:: Multi-step reaction with 14 steps

1: DMAP, PPh₃ / Ambient temperature

2: NaOMe / methanol / Ambient temperature

3: 83 percent / NBS / tetrahydrofuran

4: 79 percent / Bu₃SnCl, NaBH₄, AIBN / 2-methyl-propan-2-ol / 80 °C

5: aq. HCl / tetrahydrofuran / 0 °C

6: LiAlH₄ / diethyl ether / 0 °C

7: DMAP / dimethylformamide / Ambient temperature

8: PCC / diethyl ether / Ambient temperature

9: 1.) LDA / 1.) THF

10: 1.) NaBH₄, 2.) NaOMe / 1.) MeOH, 0 deg C, 2.) MeOH, reflux

11: NaH / dimethylformamide / Ambient temperature

12: LiAlH₄ / diethyl ether / 0 °C

13: Et₃N / CH₂Cl₂ / 0 °C

14: dimethylformamide / Ambient temperature

With hydrogenchloride; dmap; sodium tetrahydroborate; N-Bromosuccinimide; lithium aluminium tetrahydride; 2,2'-azobis(isobutyronitrile); tributyltin chloride; sodium methylate; sodium hydride; triethylamine; triphenylphosphine; pyridinium chlorochromate; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/S0960-894X(98)00315-1

Reference yield:

: 6485-40-1,2244-16-8
(R)-Carvone

: 185538-87-8
1-[(1R,2R,3S,6R)-6-Isopropenyl-2-methoxy-3-methyl-3-(2-trityloxy-ethyl)-cyclohexylmethyl]-1H-[1,2,4]triazole

Guidance literature:: Multi-step reaction with 15 steps

1: 92 percent / LiAlH₄ / diethyl ether / -78 °C

2: DMAP, PPh₃ / Ambient temperature

3: NaOMe / methanol / Ambient temperature

4: 83 percent / NBS / tetrahydrofuran

5: 79 percent / Bu₃SnCl, NaBH₄, AIBN / 2-methyl-propan-2-ol / 80 °C

6: aq. HCl / tetrahydrofuran / 0 °C

7: LiAlH₄ / diethyl ether / 0 °C

8: DMAP / dimethylformamide / Ambient temperature

9: PCC / diethyl ether / Ambient temperature

10: 1.) LDA / 1.) THF

11: 1.) NaBH₄, 2.) NaOMe / 1.) MeOH, 0 deg C, 2.) MeOH, reflux

12: NaH / dimethylformamide / Ambient temperature

13: LiAlH₄ / diethyl ether / 0 °C

14: Et₃N / CH₂Cl₂ / 0 °C

15: dimethylformamide / Ambient temperature

With hydrogenchloride; dmap; sodium tetrahydroborate; N-Bromosuccinimide; lithium aluminium tetrahydride; 2,2'-azobis(isobutyronitrile); tributyltin chloride; sodium methylate; sodium hydride; triethylamine; triphenylphosphine; pyridinium chlorochromate; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/S0960-894X(98)00315-1

Reference yield:

: 18383-51-2,22567-18-6,20307-86-2
(-)-trans-carveol

: 185538-87-8
1-[(1R,2R,3S,6R)-6-Isopropenyl-2-methoxy-3-methyl-3-(2-trityloxy-ethyl)-cyclohexylmethyl]-1H-[1,2,4]triazole

Guidance literature:: Multi-step reaction with 12 steps

1: 83 percent / NBS / tetrahydrofuran

2: 79 percent / Bu₃SnCl, NaBH₄, AIBN / 2-methyl-propan-2-ol / 80 °C

3: aq. HCl / tetrahydrofuran / 0 °C

4: LiAlH₄ / diethyl ether / 0 °C

5: DMAP / dimethylformamide / Ambient temperature

6: PCC / diethyl ether / Ambient temperature

7: 1.) LDA / 1.) THF

8: 1.) NaBH₄, 2.) NaOMe / 1.) MeOH, 0 deg C, 2.) MeOH, reflux

9: NaH / dimethylformamide / Ambient temperature

10: LiAlH₄ / diethyl ether / 0 °C

11: Et₃N / CH₂Cl₂ / 0 °C

12: dimethylformamide / Ambient temperature

With hydrogenchloride; dmap; sodium tetrahydroborate; N-Bromosuccinimide; lithium aluminium tetrahydride; 2,2'-azobis(isobutyronitrile); tributyltin chloride; sodium methylate; sodium hydride; triethylamine; pyridinium chlorochromate; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/S0960-894X(98)00315-1