Technology Process of 2H-Pyran,
tetrahydro-2-[[(3S,7R)-3,7,11-trimethyl-4-(phenylsulfonyl)dodecyl]oxy]-
There total 9 articles about 2H-Pyran,
tetrahydro-2-[[(3S,7R)-3,7,11-trimethyl-4-(phenylsulfonyl)dodecyl]oxy]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(3S)-3-methyl-4-phenylsulfonylbutyl tetrahydropyranyl ether;
With
lithium diisopropyl amide;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
at -78 ℃;
for 0.5h;
(3R)-3,7-dimethyloctyl iodide;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
at -78 - 20 ℃;
for 1h;
DOI:10.1248/cpb.48.272
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 92 percent / H2 / 20percent Pd(OH)2/C / ethyl acetate / 760 Torr / Ambient temperature
2: 90 percent / I2, Ph3P, imidazole / acetonitrile / 1.33 h / 0 - 20 °C
3: 1.) LDA, HMPA / 1.) THF, -78 deg C, 30 min, 2.) THF, a) -78 deg C, 30 min, b) 0 deg C, 30 min
With
1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; hydrogen; iodine; triphenylphosphine; lithium diisopropyl amide;
palladium dihydroxide;
In
ethyl acetate; acetonitrile;
DOI:10.1248/cpb.44.2153
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 80 percent / LiAlH4 / tetrahydrofuran / 0.25 h / 0 °C
2: 92 percent / H2 / 20percent Pd(OH)2/C / ethyl acetate / 760 Torr / Ambient temperature
3: 90 percent / I2, Ph3P, imidazole / acetonitrile / 1.33 h / 0 - 20 °C
4: 1.) LDA, HMPA / 1.) THF, -78 deg C, 30 min, 2.) THF, a) -78 deg C, 30 min, b) 0 deg C, 30 min
With
1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; hydrogen; iodine; triphenylphosphine; lithium diisopropyl amide;
palladium dihydroxide;
In
tetrahydrofuran; ethyl acetate; acetonitrile;
DOI:10.1248/cpb.44.2153
