chol-3-en-24-oic acid

Base Information

• Chemical Name: chol-3-en-24-oic acid
• CAS No.: 28083-35-4
• Molecular Formula: C24H38 O2
• Molecular Weight: 358.565
• Mol file: 28083-35-4.mol

Synonyms:5b-Chol-3-en-24-oic acid (8CI); 5b-Chol-3-enic acid (7CI);Chol-3-enoic acid

Chemical Property of chol-3-en-24-oic acid

Chemical Property:

• Vapor Pressure: 2.49E-10mmHg at 25°C
• Boiling Point: 474.9°Cat760mmHg
• PKA: 4.76±0.10(Predicted)
• Flash Point: 371.5°C
• PSA: 37.30000
• Density: 1.032g/cm³
• LogP: 6.31230

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of chol-3-en-24-oic acid

There total 11 articles about chol-3-en-24-oic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-oxo-5β-cholan-24-oate (1173-32-6) → 5β-chol-3-en-24-oic acid (28083-35-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 5.15 g / methanol; propan-1-ol / 5 h / Heating

2: 1.09 g / KH / toluene / 3 h / Heating

3: 718 mg / 1N KOH / methanol / 4 h / Heating

With potassium hydroxide; potassium hydride; In methanol; propan-1-ol; toluene;

DOI:10.1248/cpb.29.137

Reference yield:

methyl 4β-bromo-3-oxo-5β-cholan-24-oate (52032-49-2) → 5β-chol-3-en-24-oic acid (28083-35-4)

Guidance literature:

Multi-step reaction with 3 steps

1: NaBH₄; ethanol

2: zinc; acetic acid

3: ethanolic alkaline solution

With sodium tetrahydroborate; ethanol; alkaline solution; acetic acid; zinc;

DOI:10.1021/ja01103a054

Reference yield:

5β-chol-3-en-24-oic acid ethyl ester (119248-95-2) → 5β-chol-3-en-24-oic acid (28083-35-4)

Guidance literature:

With alkaline solution;

DOI:10.1021/ja01103a054

upstream raw materials:

3β-hydroxy-5β.14β.17βH.20ξH-cholanoic acid-(24)

5β-chol-3-en-24-oic acid ethyl ester

Lithocholic acid

5β-cholan-3-en-24-oic acid methyl ester

Downstream raw materials:

cholanic acid