L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-ethynyl-, methyl ester

Base Information

Chemical Name:L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-ethynyl-, methyl ester
CAS No.:188640-59-7
Molecular Formula:C17H21NO4
Molecular Weight:303.358
Hs Code.:

Synonyms:N-Boc-4-ethynyl-L-phenylalanine methyl ester;N-Boc-4-ethynyl-(S)-phenylalanine methyl ester;(S)-2-tert-Butoxycarbonylamino-3-(4-ethynyl-phenyl)-propionic acid methyl ester;N-tert-Boc-4-ethynyl-L-phenylalanine methyl ester;N-t-Boc-4-ethynyl-L-phenylalanine methylester;

Suppliers and Price of L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-ethynyl-, methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Activate Scientific
N-Boc-4-ethynyl-L-phenylalanine methyl ester 95% ee
250 mg
$ 226.00

Activate Scientific
N-Boc-4-ethynyl-L-phenylalanine methyl ester 95% ee
1 g
$ 545.00

Acrotein
N-Boc-4-ethynyl-L-phenylalaninemethylester 97%
1g
$ 421.67

Total 6 raw suppliers

Chemical Property of L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-ethynyl-, methyl ester

Chemical Property:

PSA：64.63000
LogP:2.66760

Purity/Quality:

98% ^*data from raw suppliers

N-Boc-4-ethynyl-L-phenylalanine methyl ester 95% ee ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-ethynyl-, methyl ester

There total 8 articles about L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-ethynyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 113850-76-3,210962-91-7
N-(tert-butoxycarbonyl)-4-iodo-L-phenylalanine methyl ester

: 1066-54-2
trimethylsilylacetylene

: 188640-59-7
methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-ethynylphenyl)propanoate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; gold(I) iodide; triethylamine; In acetonitrile; at 80 ℃; for 18h; Reagent/catalyst; Temperature; Kinetics; Catalytic behavior; Inert atmosphere;
DOI:10.1039/c6ob02437h

Reference yield: 77.0%

: methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-((trimethylsilyl)ethynyl)phenyl)propanoate

: 188640-59-7
methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-ethynylphenyl)propanoate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.25h; Inert atmosphere;
DOI:10.1002/anie.201705903

Reference yield:

: 103882-09-3,62129-44-6
N-Boc-4-I-Phe-OH

: 1066-54-2
trimethylsilylacetylene

: 188640-59-7
methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-ethynylphenyl)propanoate

Guidance literature:: N-Boc-4-I-Phe-OH; trimethylsilylacetylene; With copper(l) iodide; triethylamine;

With tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1016/j.tet.2013.10.072