1,2-cyclopentanediol, 3-(2-amino-6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)-, (1S,2S,3R,5R)-

Base Information

• Chemical Name: 1,2-cyclopentanediol, 3-(2-amino-6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)-, (1S,2S,3R,5R)-
• CAS No.: 108742-08-1
• Molecular Formula: C₁₁H₁₄ClN₅O₃
• Molecular Weight: 299.717
• DSSTox Substance ID: DTXSID50910862
• Wikidata: Q82880882
• Mol file: 108742-08-1.mol

Synonyms:108742-08-1;1,2-cyclopentanediol, 3-(2-amino-6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)-, (1S,2S,3R,5R)-;DTXSID50910862;(1S,2S,3R,5R)-3-(2-amino-6-chloro-purin-9-yl)-5-(hydroxymethyl)cyclopentane-1,2-diol;3-(6-Chloro-2-imino-1,2-dihydro-9H-purin-9-yl)-5-(hydroxymethyl)cyclopentane-1,2-diol

Chemical Property of 1,2-cyclopentanediol, 3-(2-amino-6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)-, (1S,2S,3R,5R)-

Chemical Property:

• Vapor Pressure: 1.14E-17mmHg at 25°C
• Boiling Point: 647.8°Cat760mmHg
• Flash Point: 345.6°C
• Density: 2.03g/cm³
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 2
• Exact Mass: 299.0785170
• Heavy Atom Count: 20
• Complexity: 365

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(C(C(C1N2C=NC3=C2N=C(N=C3Cl)N)O)O)CO
• Isomeric SMILES: C1[C@@H]([C@@H]([C@H]([C@@H]1N2C=NC3=C2N=C(N=C3Cl)N)O)O)CO

Technology Process of 1,2-cyclopentanediol, 3-(2-amino-6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)-, (1S,2S,3R,5R)-

There total 4 articles about 1,2-cyclopentanediol, 3-(2-amino-6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)-, (1S,2S,3R,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

orthoformic acid triethyl ester (122-51-0) + (+/-)-(1α,2β,3α,5α)-3-<(2,5-diamino-6-chloro-4-pyrimidyl)amino>-5-(hydroxymethyl)-1,2-cyclopentanediol (108742-07-0) → (+/-)-(1α,2β,3α,5α)-3-(2-amino-6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)-1,2-cyclopentanediol (108742-08-1,75797-17-0)

Guidance literature:

With hydrogenchloride; In N,N-dimethyl-formamide; for 24h; Ambient temperature;

DOI:10.1021/jm00394a017

Reference yield:

(+/-)-(1α,2β,3α,5α)-3-<(2-amino-6-chloro-4-pyrimidinyl)amino>-5-(hydroxymethyl)-1,2-cyclopentanediol (108742-05-8) → (+/-)-(1α,2β,3α,5α)-3-(2-amino-6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)-1,2-cyclopentanediol (108742-08-1,75797-17-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium acetate trihydrate, acetic acid / H₂O / Ambient temperature

2: 54 percent / zinc, acetic acid / H₂O; ethanol / 1.5 h / Heating

3: 52 percent / concd. HCl / dimethylformamide / 24 h / Ambient temperature

With hydrogenchloride; sodium acetate; acetic acid; zinc; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm00394a017

Reference yield:

(+/-)-(1α,2β,3α,5α)-3-<<2-amino-6-chloro-5-<(4-chlorophenyl)azo>-4-pyrimidyl>amino>-5-(hydroxymethyl)-1,2-cyclopentanediol (108742-06-9) → (+/-)-(1α,2β,3α,5α)-3-(2-amino-6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)-1,2-cyclopentanediol (108742-08-1,75797-17-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 54 percent / zinc, acetic acid / H₂O; ethanol / 1.5 h / Heating

2: 52 percent / concd. HCl / dimethylformamide / 24 h / Ambient temperature

With hydrogenchloride; acetic acid; zinc; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm00394a017

upstream raw materials:

orthoformic acid triethyl ester

(+/-)-(1α,2β,3α,5α)-3-<(2,5-diamino-6-chloro-4-pyrimidyl)amino>-5-(hydroxymethyl)-1,2-cyclopentanediol

(+/-)-(1α,2β,3α,5α)-3-<(2-amino-6-chloro-4-pyrimidinyl)amino>-5-(hydroxymethyl)-1,2-cyclopentanediol

(+/-)-(1α,2β,3α,5α)-3-<<2-amino-6-chloro-5-<(4-chlorophenyl)azo>-4-pyrimidyl>amino>-5-(hydroxymethyl)-1,2-cyclopentanediol

Downstream raw materials:

(+/-)-2-amino-1,9-dihydro-9-<(1α,2β,3α,5α)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl>-6H-purin-6-one