1-methyl-2-(4-chlorophenoxymethyl)-3-[2-[4-(piperidin-1-yl)piperidin-1-yl]-1,2-ethanedionyl]-1H-indole

Base Information

Chemical Name:1-methyl-2-(4-chlorophenoxymethyl)-3-[2-[4-(piperidin-1-yl)piperidin-1-yl]-1,2-ethanedionyl]-1H-indole
CAS No.:188721-66-6
Molecular Formula:C₂₈H₃₂ClN₃O₃
Molecular Weight:494.033
Hs Code.:
DSSTox Substance ID:DTXSID701115984
Nikkaji Number:J898.712B
ChEMBL ID:CHEMBL331202

Synonyms:CHEMBL331202;SCHEMBL7963164;GMNSKOPBGHCMQS-UHFFFAOYSA-N;DTXSID701115984;BDBM50060723;1-[1,4'']Bipiperidinyl-1''-yl-2-[2-(4-chloro-phenoxymethyl)-1-methyl-1H-indol-3-yl]-ethane-1,2-dione;1-[1,4'-Bipiperidin]-1'-yl-2-[2-[(4-chlorophenoxy)methyl]-1-methyl-1H-indol-3-yl]-1,2-ethanedione;1-[1-Methyl-2-[(4-chlorophenoxy)methyl]-1H-indol-3-yl]-2-(1,4'-bipiperidin-1'-yl)-1,2-ethanedione;1-methyl-2-(4-chlorophenoxymethyl)-3-[2-[4-(piperidin-1-yl)piperidin-1-yl]-1,2-ethanedionyl]-1H-indole;188721-66-6

Suppliers and Price of 1-methyl-2-(4-chlorophenoxymethyl)-3-[2-[4-(piperidin-1-yl)piperidin-1-yl]-1,2-ethanedionyl]-1H-indole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-methyl-2-(4-chlorophenoxymethyl)-3-[2-[4-(piperidin-1-yl)piperidin-1-yl]-1,2-ethanedionyl]-1H-indole

Chemical Property:

XLogP3:4.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:493.2132196
Heavy Atom Count:35
Complexity:729

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1C2=CC=CC=C2C(=C1COC3=CC=C(C=C3)Cl)C(=O)C(=O)N4CCC(CC4)N5CCCCC5

Technology Process of 1-methyl-2-(4-chlorophenoxymethyl)-3-[2-[4-(piperidin-1-yl)piperidin-1-yl]-1,2-ethanedionyl]-1H-indole

There total 7 articles about 1-methyl-2-(4-chlorophenoxymethyl)-3-[2-[4-(piperidin-1-yl)piperidin-1-yl]-1,2-ethanedionyl]-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1485-22-9
(1-methyl-1H-indol-2-yl)-methanol

: 188721-66-6
1-methyl-2-(4-chlorophenoxymethyl)-3-[2-[4-(piperidin-1-yl)piperidin-1-yl]-1,2-ethanedionyl]-1H-indole

Guidance literature:: Multi-step reaction with 3 steps

1: NaH / dimethylformamide / 80 °C

2: diethyl ether

3: tetrahydrofuran

With sodium hydride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm970512x

Reference yield:

: 1202-04-6
indole-2-carboxylic acid methyl ester

: 188721-66-6
1-methyl-2-(4-chlorophenoxymethyl)-3-[2-[4-(piperidin-1-yl)piperidin-1-yl]-1,2-ethanedionyl]-1H-indole

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) DMF, 2.) DMF, from 0 deg C to RT

2: LAH / tetrahydrofuran / 0 - 20 °C

3: NaH / dimethylformamide / 80 °C

4: diethyl ether

5: tetrahydrofuran

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm970512x

Reference yield:

: 37493-34-8
methyl 1-methyl-1H-indole-2-carboxylate

: 188721-66-6
1-methyl-2-(4-chlorophenoxymethyl)-3-[2-[4-(piperidin-1-yl)piperidin-1-yl]-1,2-ethanedionyl]-1H-indole

Guidance literature:: Multi-step reaction with 4 steps

1: LAH / tetrahydrofuran / 0 - 20 °C

2: NaH / dimethylformamide / 80 °C

3: diethyl ether

4: tetrahydrofuran

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm970512x