1H-Indole, 5-nitro-1-[(phenylmethoxy)methyl]-

Base Information

Chemical Name:1H-Indole, 5-nitro-1-[(phenylmethoxy)methyl]-
CAS No.:188730-25-8
Molecular Formula:C16H14N2O3
Molecular Weight:282.299
Hs Code.:
DSSTox Substance ID:DTXSID90474195
Nikkaji Number:J825.802C
Wikidata:Q82304036

Synonyms:1H-Indole, 5-nitro-1-[(phenylmethoxy)methyl]-;188730-25-8;DTXSID90474195;N-(benzyloxymethyl)-5-nitroindole

Suppliers and Price of 1H-Indole, 5-nitro-1-[(phenylmethoxy)methyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 1H-Indole, 5-nitro-1-[(phenylmethoxy)methyl]-

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:282.10044231
Heavy Atom Count:21
Complexity:352

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)COCN2C=CC3=C2C=CC(=C3)[N+](=O)[O-]

Technology Process of 1H-Indole, 5-nitro-1-[(phenylmethoxy)methyl]-

There total 1 articles about 1H-Indole, 5-nitro-1-[(phenylmethoxy)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 3587-60-8
Benzyloxymethyl chloride

: 6146-52-7
5-nitroindole

: 188730-25-8
1-Benzyloxymethyl-5-nitro-1H-indole

Guidance literature:: With sodium hydride; In tetrahydrofuran;
DOI:10.1016/S0040-4039(97)00198-6

Reference yield: 83.0%

: 3598-13-8
(4-chlorophenoxy)acetonitrile

: 188730-25-8
1-Benzyloxymethyl-5-nitro-1H-indole

: 188730-26-9
(1-Benzyloxymethyl-5-nitro-1H-indol-4-yl)-acetonitrile

Guidance literature:: With potassium tert-butylate; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(97)00198-6

Reference yield:

: 188730-25-8
1-Benzyloxymethyl-5-nitro-1H-indole

: 188730-31-6
3-Benzyloxymethyl-3,6-dihydro-pyrrolo[3,2-e]indole-1,8-dicarbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / KOt-Bu / dimethylformamide

2: 62 percent / H₂ / 10percent Pd/C / ethanol / 12 h / 45 °C

3: 68 percent / 1.) POCl₃, 2.) NaOH, H₂O / dimethylformamide / 2.) heating

With sodium hydroxide; potassium tert-butylate; water; hydrogen; trichlorophosphate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(97)00198-6