4-Imidazolidinecarboxylic acid, 1-[(S)-(4-methylphenyl)sulfinyl]-2,5-diphenyl-4-(phenylmethyl)-, methyl ester, (2S,4R,5R)-

Base Information

• Chemical Name: 4-Imidazolidinecarboxylic acid, 1-[(S)-(4-methylphenyl)sulfinyl]-2,5-diphenyl-4-(phenylmethyl)-, methyl ester, (2S,4R,5R)-
• CAS No.: 188760-06-7
• Molecular Formula: C31H30N2O3S
• Molecular Weight: 510.657
• Mol file: 188760-06-7.mol

Synonyms:

Chemical Property of 4-Imidazolidinecarboxylic acid, 1-[(S)-(4-methylphenyl)sulfinyl]-2,5-diphenyl-4-(phenylmethyl)-, methyl ester, (2S,4R,5R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Imidazolidinecarboxylic acid, 1-[(S)-(4-methylphenyl)sulfinyl]-2,5-diphenyl-4-(phenylmethyl)-, methyl ester, (2S,4R,5R)-

There total 3 articles about 4-Imidazolidinecarboxylic acid, 1-[(S)-(4-methylphenyl)sulfinyl]-2,5-diphenyl-4-(phenylmethyl)-, methyl ester, (2S,4R,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

(E)-2-(benzylidene-amino)-3-phenyl-propionic acid methyl ester (339190-42-0) + (S,E)-N-benzylidene-4-methylbenzenesulfinamide (350479-90-2) → methyl [(2R,4S,5S,SS)-4-benzyl-2,5-diphenyl-1-(p-tolylsulfinyl)-1,3-imidazolidin-4-yl]carboxylate (188760-07-8) + (-)-methyl [(2S,4R,5R,SS)-4-benzyl-2,5-diphenyl-1-(p-tolylsulfinyl)-1,3-imidazolidin-4-yl]carboxylate (188760-06-7)

Guidance literature:

(E)-2-(benzylidene-amino)-3-phenyl-propionic acid methyl ester; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.416667h;

(S,E)-N-benzylidene-4-methylbenzenesulfinamide; In tetrahydrofuran; at -78 - 4 ℃; for 20h; Further stages.;

DOI:10.1002/chem.200204674

Reference yield: 25.0%

(E)-2-(benzylidene-amino)-3-phenyl-propionic acid methyl ester (339190-42-0) + (S,E)-N-benzylidene-4-methylbenzenesulfinamide (350479-90-2) → methyl [(2R,4S,5S,SS)-4-benzyl-2,5-diphenyl-1-(p-tolylsulfinyl)-1,3-imidazolidin-4-yl]carboxylate (188760-07-8) + (-)-methyl [(2S,4R,5R,SS)-4-benzyl-2,5-diphenyl-1-(p-tolylsulfinyl)-1,3-imidazolidin-4-yl]carboxylate (188760-06-7) + methyl [(2R,4R,5S,SS)-4-benzyl-2,5-diphenyl-1-(p-tolylsulfinyl)-1,3-imidazolidin-4-yl]carboxylate + (-)-methyl [(2S,4S,5R,SS)-4-benzyl-2,5-diphenyl-1-(p-tolylsulfinyl)-1,3-imidazolidin-4-yl]carboxylate (596823-56-2)

Guidance literature:

(E)-2-(benzylidene-amino)-3-phenyl-propionic acid methyl ester; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h;

(S,E)-N-benzylidene-4-methylbenzenesulfinamide; With boron trifluoride diethyl etherate; In tetrahydrofuran; at -78 - 20 ℃; for 12h;

In chloroform; at 20 ℃; Further stages. Further byproducts.;

DOI:10.1002/chem.200204674

Reference yield:

(S,E)-N-benzylidene-4-methylbenzenesulfinamide (350479-90-2) + C17H16NO2(1-)*Li(1+) → methyl [(2R,4S,5S,SS)-4-benzyl-2,5-diphenyl-1-(p-tolylsulfinyl)-1,3-imidazolidin-4-yl]carboxylate (188760-07-8) + (-)-methyl [(2S,4R,5R,SS)-4-benzyl-2,5-diphenyl-1-(p-tolylsulfinyl)-1,3-imidazolidin-4-yl]carboxylate (188760-06-7)

Guidance literature:

In tetrahydrofuran; at -78 - 4 ℃; for 20h; Yield given. Yields of byproduct given;

DOI:10.1021/jo970005n

upstream raw materials:

(S,E)-N-benzylidene-4-methylbenzenesulfinamide

(E)-2-(benzylidene-amino)-3-phenyl-propionic acid methyl ester

Downstream raw materials:

(-)-[(2S,4R,5R)-4-benzyl-2,5-diphenyl-1-(p-tolylsulfenyl)-1,3-imidazolidin-4-yl]methanol

(-)-methyl [(2S,4R,5R)-4-benzyl-2,5-diphenyl-1-(p-tolylsulfonyl)-1,3-imidazolidin-4-yl]carboxylate