Technology Process of Hexanoic acid, 4-[bis(phenylmethyl)amino]-5-methyl-3-oxo-,
1,1-dimethylethyl ester, (R)-
There total 5 articles about Hexanoic acid, 4-[bis(phenylmethyl)amino]-5-methyl-3-oxo-,
1,1-dimethylethyl ester, (R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: K2CO3 / acetone / 1.) room temperature, 1 h, 2.) reflux, overnight
2: 1.) Tf2O, 2,6-lutidine / 1.) CH2Cl2, 0 deg C, 15 min, 2.) room temperature, 2 h
3: 79 percent / LiI, NaCN / pyridine / 24 h / Heating
4: 1.) CDI, 2.) imidazole / 1.) THF, room temperature, 1 h, 2.) -78 deg C, 50 min
With
1H-imidazole; 2,6-dimethylpyridine; trifluoromethylsulfonic anhydride; sodium cyanide; potassium carbonate; 1,1'-carbonyldiimidazole; lithium iodide;
In
pyridine; acetone;
DOI:10.1021/jo961836g
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) Tf2O, 2,6-lutidine / 1.) CH2Cl2, 0 deg C, 15 min, 2.) room temperature, 2 h
2: 79 percent / LiI, NaCN / pyridine / 24 h / Heating
3: 1.) CDI, 2.) imidazole / 1.) THF, room temperature, 1 h, 2.) -78 deg C, 50 min
With
1H-imidazole; 2,6-dimethylpyridine; trifluoromethylsulfonic anhydride; sodium cyanide; 1,1'-carbonyldiimidazole; lithium iodide;
In
pyridine;
DOI:10.1021/jo961836g
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 79 percent / LiI, NaCN / pyridine / 24 h / Heating
2: 1.) CDI, 2.) imidazole / 1.) THF, room temperature, 1 h, 2.) -78 deg C, 50 min
With
1H-imidazole; sodium cyanide; 1,1'-carbonyldiimidazole; lithium iodide;
In
pyridine;
DOI:10.1021/jo961836g
