Glycine, N-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-N-[[4-[(4-methoxybenz oyl)amino]-2-oxo-1(2H)-pyrimidinyl]acetyl]-, 1,1-dimethylethyl ester

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Chemical Name:Glycine, N-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-N-[[4-[(4-methoxybenz oyl)amino]-2-oxo-1(2H)-pyrimidinyl]acetyl]-, 1,1-dimethylethyl ester
CAS No.:188779-58-0
Molecular Formula:C27H37N5O8
Molecular Weight:559.619
Hs Code.:

Glycine,
N-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-N-[[4-[(4-methoxybenz
oyl)amino]-2-oxo-1(2H)-pyrimidinyl]acetyl]-, 1,1-dimethylethyl ester

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Chemical Property of Glycine, N-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-N-[[4-[(4-methoxybenz oyl)amino]-2-oxo-1(2H)-pyrimidinyl]acetyl]-, 1,1-dimethylethyl ester

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Technology Process of Glycine, N-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-N-[[4-[(4-methoxybenz oyl)amino]-2-oxo-1(2H)-pyrimidinyl]acetyl]-, 1,1-dimethylethyl ester

There total 1 articles about Glycine, N-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-N-[[4-[(4-methoxybenz oyl)amino]-2-oxo-1(2H)-pyrimidinyl]acetyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 188779-56-8
tert-butyl N-(2-Boc-aminoethyl)glycinate

: 172405-10-6
[4-(4-Methoxybenzoylamino)-2-oxo-1,2-dihydropyrimidin-1-yl]acetic acid

: 188779-58-0
((2-tert-Butoxycarbonylamino-ethyl)-{2-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-acetyl}-amino)-acetic acid tert-butyl ester

Guidance literature:: With propylphosphonic anhydride; triethylamine; In ethyl acetate; for 2.5h;
DOI:10.1016/S0040-4020(97)01044-2

Reference yield:

: 188779-58-0
((2-tert-Butoxycarbonylamino-ethyl)-{2-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-acetyl}-amino)-acetic acid tert-butyl ester

: [{2-[4-(4-Methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-acetyl}-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-amino]-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 13.08 g / CF₃COOH / CH₂Cl₂ / 2 h / Ambient temperature

2: NEt₃ / dimethylformamide

With triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(97)01044-2