Glycine, N-[[2-(acetylamino)-6-[[(diphenylamino)carbonyl]oxy]-9H-purin-9-yl]acet yl]-N-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Glycine, N-[[2-(acetylamino)-6-[[(diphenylamino)carbonyl]oxy]-9H-purin-9-yl]acet yl]-N-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-, 1,1-dimethylethyl ester
CAS No.:188779-62-6
Molecular Formula:C35H42N8O8
Molecular Weight:702.767
Hs Code.:

Glycine,
N-[[2-(acetylamino)-6-[[(diphenylamino)carbonyl]oxy]-9H-purin-9-yl]acet
yl]-N-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-, 1,1-dimethylethyl
ester

Synonyms:

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Chemical Property of Glycine, N-[[2-(acetylamino)-6-[[(diphenylamino)carbonyl]oxy]-9H-purin-9-yl]acet yl]-N-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-, 1,1-dimethylethyl ester

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Technology Process of Glycine, N-[[2-(acetylamino)-6-[[(diphenylamino)carbonyl]oxy]-9H-purin-9-yl]acet yl]-N-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-, 1,1-dimethylethyl ester

There total 2 articles about Glycine, N-[[2-(acetylamino)-6-[[(diphenylamino)carbonyl]oxy]-9H-purin-9-yl]acet yl]-N-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 188779-56-8
tert-butyl N-(2-Boc-aminoethyl)glycinate

: 172405-25-3
(2-Acetylamino-6-diphenylcarbamoyloxy-purin-9-yl)-acetic acid

: 188779-62-6
[[2-(2-Acetylamino-6-diphenylcarbamoyloxy-purin-9-yl)-acetyl]-(2-tert-butoxycarbonylamino-ethyl)-amino]-acetic acid tert-butyl ester

Guidance literature:: With O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 16h; Ambient temperature;
DOI:10.1016/S0040-4020(97)01044-2

Reference yield:

: 112233-74-6
N₂-acetyl-O₆-(diphenylcarbamoyl)guanine

: 188779-62-6
[[2-(2-Acetylamino-6-diphenylcarbamoyloxy-purin-9-yl)-acetyl]-(2-tert-butoxycarbonylamino-ethyl)-amino]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / N,N-diisopropylethylamine / dimethylformamide

2: 81 percent / aq.NaOH / methanol; dioxane; H₂O

3: 91 percent / O-<(cyano(ethoxycarbonyl)methylene)amino>-1,1,3,3-tetramethyluronium tetrafluoroborate, N,N-diisopropylethylamine / dimethylformamide / 16 h / Ambient temperature

With sodium hydroxide; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(97)01044-2

Reference yield:

: 188779-62-6
[[2-(2-Acetylamino-6-diphenylcarbamoyloxy-purin-9-yl)-acetyl]-(2-tert-butoxycarbonylamino-ethyl)-amino]-acetic acid tert-butyl ester

: [[2-(2-Acetylamino-6-oxo-1,6-dihydro-purin-9-yl)-acetyl]-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-amino]-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 8.1 g / CF₃COOH / CH₂Cl₂ / 2 h / Ambient temperature

2: NEt₃ / dimethylformamide

With triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(97)01044-2