4-AMinoantipyrine N-CarbaMic Acid Methyl Ester

Base Information

• Chemical Name: 4-AMinoantipyrine N-CarbaMic Acid Methyl Ester
• CAS No.: 10077-96-0
• Molecular Formula: C13H15 N3 O3
• Molecular Weight: 261.2765
• Mol file: 10077-96-0.mol

Synonyms:3-Pyrazoline-4-carbamicacid, 2,3-dimethyl-5-oxo-1-phenyl-, methyl ester (6CI,7CI,8CI)

Chemical Property of 4-AMinoantipyrine N-CarbaMic Acid Methyl Ester

Chemical Property:

• Melting Point: 182-185°C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 68.75000
• Density: 1.3g/cm³
• LogP: 1.67630
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-AminoantipyrineN-CarbamicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Antipyrine derivative.

Technology Process of 4-AMinoantipyrine N-CarbaMic Acid Methyl Ester

There total 4 articles about 4-AMinoantipyrine N-CarbaMic Acid Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one (83-07-8) + methyl chloroformate (79-22-1) → (1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-carbamidsaeuremethylester (10077-96-0)

Guidance literature:

With sodium carbonate; at 40 - 42 ℃; for 0.833333h;

DOI:10.1007/BF00759469

Reference yield: 83.0%

4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one (83-07-8) + carbonic acid dimethyl ester (616-38-6) → (1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-carbamidsaeuremethylester (10077-96-0)

Guidance literature:

With 18-crown-6 ether; sodium hydride; at 50 ℃; for 8h;

Reference yield:

(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-carbothioamidoic acid O-methyl ester (100374-19-4) → (1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-carbamidsaeuremethylester (10077-96-0)

Guidance literature:

With potassium hydroxide; water; dihydrogen peroxide;

upstream raw materials:

(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-carbothioamidoic acid O-methyl ester

4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one

methyl chloroformate

carbonic acid dimethyl ester

Downstream raw materials:

N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl-)-N-methyl-carbamidsaeuremethylester